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Full-Text Articles in Life Sciences
Locus Coeruleus And Hippocampal Tyrosine Hydroxylase Levels In A Pressure-Overload Model Of Heart Disease, Luke A. Johnson
Locus Coeruleus And Hippocampal Tyrosine Hydroxylase Levels In A Pressure-Overload Model Of Heart Disease, Luke A. Johnson
Undergraduate Honors Theses
Studies have indicated that approximately 30% of people with heart disease experience major depressive disorder (MDD). Despite strong clinical evidence of a link between the two diseases, the neurobiological processes involved in the relationship are poorly understood. A growing number of studies are revealing similar neuroanatomical and neurochemical abnormalities resulting from both depression and heart disease. The locus coeruleus (LC) is a group of neurons in the pons that synthesize and release norepinephrine, and that is known to play a significant role in depression pathobiology. For example, there is evidence that tyrosine hydroxylase (TH) is elevated in the LC in …
Functional Roles Of The Insulin-Regulated Glucose Transporter-4 In The Hippocampus, Jiah Pearson-Leary
Functional Roles Of The Insulin-Regulated Glucose Transporter-4 In The Hippocampus, Jiah Pearson-Leary
Legacy Theses & Dissertations (2009 - 2024)
Although a great deal of research has elucidated both localization and function of many glucose transporters (GluTs) throughout the brain, the function of brain insulin-responsive glucose transporter-4 (GluT4) remains unclear (McEwen & Reagan, 2004). Because type 2 diabetes mellitus (T2DM; insulin resistance, i.e., impaired insulin signaling) is a risk factor for Alzheimer's disease (AD), and because the signaling mechanisms insulin uses to mediate hippocampal processes and memory are unclear, a major purpose of this dissertation was to determine whether hippocampal GluT4, which is responsible for insulin's glucoregulatory and canonical effects in the periphery, is necessary for insulin's effects in the …