Open Access. Powered by Scholars. Published by Universities.®
- Discipline
Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
Site And Mechanism Of Leptin's Antisteatotic And Insulin Sensitizing Actions In Lipodystrophic Liver, Esra Asilmaz
Site And Mechanism Of Leptin's Antisteatotic And Insulin Sensitizing Actions In Lipodystrophic Liver, Esra Asilmaz
Student Theses and Dissertations
An adipocyte hormone which functions as the afferent signal in a negative feedback loop regulating energy balance, has profound effects on glucose and lipid metabolisms. Lipodystrophic humans and mice have a complete or partial absence of adipose tissue and a secondary reduction of leptin. This is associated with insulin resistance and hepatic steatosis, which are corrected by leptin administration. This thesis aimed to define the site of leptin action and understand the molecular basis of leptin's insulin sensitizing and antisteatotic effects in lipodystrophy. To determine the site of leptin action, we treated lipodystrophic aP2-nSREBP-lc mice with a low dose of …
Life Without Gpr7, The Neuropeptide W1 Receptor: Regulation Of Energy Homeostasis By Gpr7 And Its Endogenous Neuropeptide Ligands, Makoto Ishii
Student Theses and Dissertations
Classic lesion experiments from the 1940s have established the hypothalamus as playing an essential role in controlling energy homeostasis. Gold-thioglucose (GTG) induces lesions in the ventromedial nucleus of the hypothalamus (VMH) resulting in hyperphagia and obesity. To identify genes involved in the hypothalamic regulation of energy homeostasis, we employed a screen to search for genes that were dysregulated in GTG induced obese mice. In this screen, GPR7, the endogenous G protein-coupled receptor (GPCR) for the recently identified ligands neuropeptide B (NPB) and neuropeptide W (NPW), was found to be specifically down-regulated after GTG treatment. The physiological role of GPR7 was …
Leptin In Horses: Influences Of Body Condition, Gender, Insulin Insensitivity, Feeding, And Dexamethasone, Joshua Allen Cartmill
Leptin In Horses: Influences Of Body Condition, Gender, Insulin Insensitivity, Feeding, And Dexamethasone, Joshua Allen Cartmill
LSU Doctoral Dissertations
The experiments described herein were designed to answer questions that arose from initially attempting to determine whether treatment with dexamethasone increased concentrations of leptin in geldings. Dexamethasone treatment did in fact increase leptin concentrations in mares, geldings, and stallions. Additional experiments were designed to determine leptin's interaction, not only with the adrenal axis, but with the thyroid axis, the growth hormone/insulin-like growth factor-1 axis, as well as glucose and insulin metabolism in geldings, mares, and stallions. During the course of these experiments, differences in leptin concentrations in the horse were attributed to degree of body condition, gender, and feeding time. …