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A Novel Subfamily Of Three Star-Related Lipid Transfer Proteins That Are Differentially-Regulated And Function In Intracellular Cholesterol Metabolism, Raymond E. Soccio
A Novel Subfamily Of Three Star-Related Lipid Transfer Proteins That Are Differentially-Regulated And Function In Intracellular Cholesterol Metabolism, Raymond E. Soccio
Student Theses and Dissertations
thesis describes the discovery, cloning, and initial characterization of StarD4, sterol-regulated gene encoding a StAR-related lipid transfer (START) protein, and its close homologues, StarD5 and StarD6. StarD4 was identified using cDNA microarrays, as liver StarD4 expression decreased three-fold in mice fed a high cholesterol diet. StarD4 also sterol-regulated in cultured cells, and a functional sterol regulatory element (SRE) identified in its promoter. StarD4 was preferentially activated in mouse liver by SREBP-rather than SREBP-1, supporting a role in cholesterol rather than fatty acid metabolism. X-ray crystal structure of StarD4 was solved, revealing a hydrophobic lipid binding cavity described for other START …
Fecal Steroid Excretion Of Rats Fed Rice Bran Oil And Oryzanol, Zhaoli Dai
Fecal Steroid Excretion Of Rats Fed Rice Bran Oil And Oryzanol, Zhaoli Dai
LSU Master's Theses
Rice bran oil (RBO) has been considered healthy cooking oil with potent effects to reduce the risks of atherosclerosis and coronary heart disease. The relatively high level of unsaponifiable components contributes to the healthy benefits of RBO. This study investigated the possibility that the cholesterol-lowering effects of oryzanol are through increased fecal steroid excretion. The objective was to compare fecal cholesterol and bile acid excretion as well as bioavailability among different forms of oryzanol. The correlation between bioactivity and bioavailability of oryzanol was investigated as well. Forty-seven female breeder rats were used as animal models. Oryzanol was added to an …