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Roles For The E3 Ligase Itch In Immune Response Modulation, Sukhvinder Kaur Sahota

Student Theses and Dissertations

Cloning of the inversion breakpoints in the agouti mutant strain a has implicated the E3 ligase Itch in the spontaneous inflammation that occurs in these mice. 1 RH Anaylsis of a mice suggests that the inflammatory disease is due to a dysregulated T helper type-2 immune response. In order to verify the importance of Itch inactivation in the spontaneous inflammation of a mice and to determine which cell type is responsible for the pathology, the Itch gene has been targeted for conditional deletion in mice using the Cre-loxP system. The results presented in this thesis provide the first direct evidence …