Life Sciences Commons^™

Irritable Bowel Syndrome, Eating Disorders, And Mental Stress Among United Arab Emirates University Students, Maram Braikan Alotaibi

Theses

Irritable Bowel Syndrome (IBS), Eating Disorders (EDs), and mental stress are understudied in the United Arab Emirates (UAE), especially among university students. The objective of this study is to assess the prevalence of IBS, ED, mental stress, their associations, and the determinants of IBS among United Arab Emirates University (UAEU) students. An observational cross-sectional study was conducted via a 48-item online-survey shared with 14,268 undergraduate/graduate students, registered during academic year 2021-2022 in UAEU. Logistic regression models were performed to examine the predictive factors associated with IBS among UAEU students in total and by ED status. Significance was determined at p< 0.05. The prevalence of IBS was 39%, ED 55.9%, and high mental stress 53.2%, and they co-existed in 15.9% of UAEU students. Students who reported consuming trigger-food were 6 times more likely to have IBS than their counterpart [AOR: 5.859; 95% CI: 3.092–11.102, p< 0.001]. Those who reported intakes of relief-food were 4 times more likely to have IBS compared to their counterpart [AOR: 3.881; 95% CI: 1.669 – 9.022, p=0.002]. Students with family history of IBS (FHIBS) were 2.6 times more likely to have IBS than their counterpart [AOR: 2.572; 95% CI: 1.420–4.660, p= 0.002]. Students with high mental stress were 1.7 times more likely to have IBS than those with low-moderate stress, when adjusted for sex and age [AOR:1.730; 1.058–2.830, p= 0.029). No significant associations existed between IBS and ED, Socioeconomic Characteristics (SEC), lifestyle, dietary, and health-related factors. UAEU students reported high prevalence of IBS, ED and mental stress. A significant relationship was found between IBS and FH-IBS, trigger- and relieving- food. This study confirmed the prevalence of IBS, ED and mental stress. Large cohort studies on university students in the UAE are warranted to establish the relationships among IBS, ED, mental stress and their determinants.

Canagliflozin Ameliorates Autistic-Like Features And Mitigates Brain Oxidative Stress Levels In Valproic Acid-Induced Autism In Rats, Mohammad Moutaz Nakhal

Theses

Autism spectrum disorder (ASD) is a neurodevelopmental disease with a substantially increasing incidence rate. It is mainly characterized by repetitive behavior, intellectual difficulties, social communication and interactions deficits. Many medications, dietary supplements, and behavioral treatments have been recommended for ASD management, however, there is no cure yet. Recent studies have examined the therapeutic potential of the sodium-glucose cotransporter 2 (SGLT2) inhibitors in neurodevelopmental diseases, based on their proved anti-inflammatory and antioxidant effects. The main objective of this study is to assess the ability of canagliflozin in improving the behavioural characteristics of autistic rats and investigate the efficacy of canagliflozin in …

Biochemical Characterization Of Date Palm (Phoniex Dactylifera L) Seeds Maintained At Microgravity In Outer Space Iss, Shamma Khalid Aldhaheri

Theses

The UAE’s vision to reach space dates to 1976 when Sheikh Zayed Bin Sultan Al Nahyan met with the National Aeronautics and Space Administration (NASA) Apollo group; this meeting marked the first attempt of UAE to enter the field of space science. The UAE is currently one of the top countries executing space missions and research. This research focuses on the biochemical characterization of date palm seeds that are sent to the International Space Station (ISS) in outer space. The research methodology involves biochemical analysis of seeds maintained under two different environmental conditions-microgravity and standard gravity. In total, 30–45 seeds …

Understanding The Intracellular Positive Regulatory Interactions In The Metabolic Network, Sultana Mohammed Al Zubaidi

Theses

Metabolism is an essential cellular process that produces essential components such as energy molecules and cellular building blocks. It is regulated by intracellular metabolite-enzyme interactions, which can increase or decrease enzyme efficiency. Each metabolic process is not evolved in nature and may not contribute to the optimal efficiency of the organism's metabolism. However, this study aims to clarify the relationship between cellular positive regulatory interactions and the cell's metabolic network, especially how these relationships regulate metabolism and how it evolved in nature. To obtain that, for each enzyme, the activation molecules from the BRENDA database were downloaded, mapped data to …

Standardizing Sustainable Aquaponic Production Of Leafy Greens And Fish: A Comparison With Conventional Systems In The United Arab Emirates, Drishya Nishanth

Theses

The production of leafy green vegetables through aquaponics is established worldwide, but the production of herbs which are used in day-to-day life in the United Arab Emirates is not yet explored in this system in terms of production efficiency, water usage and the nutrient parameters. In the current study, basil (Ocimum basilicum L.) and coriander (Coriandrum sativum L.), the two commonly used herbs, were grown in a traditional aquaponics system using tilapia fish and catfish effluent water (soil-less agriculture) and an irrigation-based greenhouse cultivation system (soil cultivation). The study's major goal is to evaluate several growth techniques for …

Characterization And Genomic Analysis Of Two Escherichia Coli O157:H7 Bacteriophages Isolated From Pigeons, Mohamad I. Alolama

Dissertations

Enterohemorrhagic Escherichia coli, also known as EHEC, is a subset of Shiga toxin-producing E. coli (STEC), and it has recently been identified as one of the principal foodborne pathogens. E. coli O157:H7 is the most important serotype of STEC for its role in causing foodborne illnesses. E. coli O157:H7 could cause various gastroenteritis symptoms such as diarrhea, hemolytic uremic syndrome, hemorrhagic colitis, and thrombotic thrombocytopenic purpura and may cause death. Elimination of E. coli O157:H7 during food processing and storage is a possible solution. Bacteriophages have a significant impact on bacterial populations in nature due to their ability to …

Maternal Effects On Growth Parameters Of Chloris Gayana Under Co2 Enrichment, Ahmed Adnan Mohammed Mashli

Theses

Rhodes grass, Chloris gayana, is commonly used forage plant for grazers, livestock, and cattle. It significantly improves soil fertility and its overall structure by preventing nematode flourishment in soil. It is also used as a cover crop to upgrade soil health by reducing soil erosion and increasing water availability. The present study assessed the effects of CO₂ on the growth, development and maternal effects of C. gayana. The experimental setup was made in such a way that the potential impacts of CO₂ can be measured on the eco-physiological growth of C. gayana by studying successive generations. Generation 1 …

The Effect Of Licogliflozin (Sglt1/2 Inhibitor) On Diabetes And Cardiac Complications, Alanoud Gharib Alblooshi

Theses

Diabetes mellitus (DM) is a chronic endocrine disease affecting millions of people worldwide. In spite of the advances made in the management of DM, poor glycemic control and diabetes complications are still very common. There is a continuous search for new and more effective drugs to treat DM. One of the drugs currently in clinical trials for the treatment of DM is licogliflozin (LIK066), a dual SGLT1/2 inhibitor, which can be used to treat obesity and diabetes. LIK066 inhibits glucose reabsorption in the kidney and small intestine, thereby reducing hyperglycemia. This study aims to investigate the efficacy of licogliflozin on …

Lactic Acid Bacteria Isolated From Fresh Vegetable Products: Potential Probiotic And Postbiotic Characteristics Including Immunomodulatory Effects, Fatima Khaled Alameri

Theses

The ability to perform effectively in the gastrointestinal system (GIT) is one of the most significant criteria for selecting the best probiotic bacteria. Thus, the present study aimed to investigate the potential probiotic characteristics of some selected lactic acid bacteria (LAB) isolated from vegetable products. Probiotic characteristics included tolerance to acid and bile, cholesterol removing ability, bile salt hydrolysis, resistance against lysozyme and antibiotics, production of exopolysaccharides (EPS), antimicrobial and hemolytic activities, and cell surface characteristics (auto-aggregation, co-aggregation, and hydrophobicity). Out of 46 isolates, 17 isolates that exhibited remarkable survivability under gastrointestinal conditions were selected for further analysis. Almost all …

Screening For Endophytic Actinobacteria To Enhance Growth And Salinity Tolerance Of Tomato Plants In The United Arab, Amira Hamdy Hassan

Theses

Salinity is one of the most decisive environmental factors limiting the productivity of crop plants, mainly in arid and semi-arid regions. An eco-friendly technology can be used to boost crop production in saline areas by using plant growth-bacteria. Endophytic actinobacteria that produce the enzyme 1-Aminocyclopropane-1-Carboxylic acid (ACC) Deaminase (ACCD) can modulate the levels of Ethylene (ET) in plants to reduce the effect of abiotic stresses including high salt stress. The main objectives of this study were to: (1) Evaluate endophytic actinobacterial isolates from healthy tomato plants cultivated in the UAE that are capable of producing ACCD in vitro; (2) …

Effect Of Carnosol On G Protein-Coupled Receptor Signaling In Cancer Cells, Laith Jehad Ahmad Abudawood

Theses

Carnosol is a plant polyphenol compound known for its beneficial properties against human diseases such as cancer and diabetes. However, the exact molecular and cellular mechanisms involved, and its molecular targets are not fully known. Carnosol was shown to bind and to modulate specific intracellular signaling proteins in cancer cell lines. In this study, we hypothesized that carnosol may pharmacologically target specific cell surface receptors including G Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinase (RTKs). Therefore, we tested the pharmacological effect of carnosol on the following receptors: Insulin Receptor (IR), Chemokine CXCL12 Receptor (CXCR4), Angiotensin II (AngII) Receptor (AT1R), Glucagon-Like …

Heterodimerization Between Chemokine Receptors Cxcr4 And Ccr7 And Its Role In Cancer, Maryam Naveed Muhammad Tariq

Theses

In physiology, the functional and physical interactions between cell surface receptors for signal molecules such as hormones, neurotransmitters, and cytokines, provides an important mechanism of diversity and regulation of signal transduction. Therefore, investigating the functional interactions between these receptors is of great importance for understanding their role in physiology and pathophysiology with potential application in drug discovery. In this context, numerous evidences support the implication of two chemokine receptors, CXCR4 and CCR7, in many cancer types. In this study, we hypothesized that the functional, and perhaps the physical interaction, occurring between CXCR4 and CCR7 may constitute one of the key …

Correlation Of Gut Alteration With The Progression Of Experimental Autoimmune Encephalomyelitis (Eae) In C57bl/6 Mice, Al Anood Ahmed Al Naqbi

Theses

Background: Experimental autoimmune encephalomyelitis (EAE) is the mouse disease model of multiple sclerosis (MS), a chronic autoimmune disease targeting the central nervous system (CNS) resulting in neuroinflammation, neuroaxonal degeneration, and demyelination. Autoreactive CD4⁺ T cells are known for their role in the pathogenesis of MS. CD8⁺ T cells and NK cells were also found to be associated with the disease.

Aim: There is a limited number of studies investigating the link between gut alterations and immune cells in the gut influencing the outcome of the disease since the vast majority of MS patients experience gastrointestinal (GI) problems. Here, …

Sources And Distribution Of Microplastics In The United Arab Emirates, Rana Zeeshan Habib

Dissertations

Microplastics (plastic pieces size) are an emerging environmental contaminant that is ubiquitously present in terrestrial, aquatic and aerial environments. United Arab Emirates (UAE) is categorized among the highest domestic waste producing countries (on per capita basis) in the world. A large portion of waste ends up in the environment and contains macro-, meso- and microplastics. No comprehensive study has been carried out in the UAE to investigate the abundance, sources, distribution and impact of microplastics on its environment. Therefore, a comprehensive study to analyze the sources and distribution of microplastics in the UAE was urgently needed. The objective of the …

Rhizosphere-Competent Actinobacterial Isolates With Acc Deaminase Activity Alleviate Salt Stress In Tomato Plants In The Uae, Alaa Ahmed Abbas Elbadawi

Biology Theses

Tomato (Solanum lycopersicum) is one of the most popular vegetables in the world, including the United Arab Emirates (UAE). Salinity is a global menace to plant growth and development, causing significant economic losses to tomato and other crop plants. It is well-known that 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase (ACCD) can increase plant tolerance to environmental stresses. This can be attributed to the increased activity of the enzyme ACCD, which breaks down ACC [the immediate precursor of ethylene (ET)] to ammonia and α-ketobutyrate, to lower the overproduction of ET levels in planta and to reduce the damages caused …

Distribution Modelling Of Socotra Cormorant Using Maxent, Areej Mustafa Jaradat

Theses

This thesis is concerned with species distribution modeling of the Socotra Cormorant (Phalacrocorax nigrogularis), a regionally endemic seabird to the Arabian Gulf, the Arabian Sea, and the Gulf of Aden. Socotra Cormorants are important for the marine ecosystem as they apply top-down control and maintain the balance between trophic levels. They also contribute to the cycling of nutrients significantly. The bird is categorized as vulnerable by the IUCN. Large portions of their suitable habitat are disturbed or degraded due to oil exploration and coastal development. The seabird is poorly studied in every ecological aspect. The main objective of …

Factors Affecting The Antibacterial Activity Of Cefiderocol On Klebsiella Pneumoniae With Diverse Characteristics, Lana Jamal Rashed Daoud

Theses

Antimicrobial resistance (AMR) is a growing serious threat that poses a burden on the healthcare system. Spread of AMR bacteria limits treatment options; thus, new antimicrobial agents are required. Cefiderocol (CFDC) is a novel siderophore cephalosporin, approved by the FDA in 2019 for use in treating infections caused by multi-drug resistant (MDR) pathogens; but it is not yet in clinical use in the UAE. CFDC is equipped with stabilizers against β-lactamases as well as a siderophore side chain that allows it to penetrate the outer membrane of bacteria through the iron uptake pathways. The aim of this study is to …

Impact Of Saline Water Irrigation On Date Palm (Phoenix Dactylifera) Associated Bulk Soil Bacterial Communities In Oases Agroecosystem Of Uae, Fardous Abdi Ibrahim Jibar Alhashmi

Theses

Irrigation of date palm (Phoenix dactylifera) with saline groundwater is routinely practiced in the arid agroecosystems of United Arab Emirates (UAE), due to freshwater scarcity. Saline groundwater irrigation is known to deposit salts in the top layers of soil and increase soil salinization. However, how increasing soil salinization affects the belowground bacterial communities, is not well investigated. Soil samples were collected from 14 different date farms where irrigation water source was either non–saline water or saline groundwater. Soil bacterial communities were identified using 16S rRNA gene metabarcoding. The results showed that bacterial diversity (including Shannon diversity, richness, and …

Mechanistic Insights On The Role Of Ambrisentan, An Endothelin Type-A Receptor Antagonist, In Breast Cancer, Ruba Saleem Lutfi Amer

Theses

The activation of the endothelin receptor type A (ETAR) by its ligand endothelin-1 (ET-1) is well known for its role in vasoconstriction. Interestingly, ET-1 and ETAR are over-expressed in various human tumours, including breast cancer. Several studies described the important role of ETAR in cancer progression and metastasis. The extensive network of interactions that exist between the ET-1 axis and other signalling pathways can trigger autocrine and paracrine signalling that modulates different tumorigenesis processes, such as cellular proliferation and survival, epithelial-to-mesenchymal transition (EMT) and chemoresistance. The main objective of this study was to investigate the antitumor effects of Ambrisentan, a …

Yield, Nutrient Contents And Antioxidant Levels In Basil (Ocimum Basilicum L.) Grown In Aquaponic And Soil Systems, Maryam Ahmed Albedwawi

Theses

A study was conducted to evaluate the performance of Ocimum basilicum L. in both aquaponic and soil systems in the UAE climatic condition. The experiments were conducted under greenhouse conditions. Plants were raised in aquaponic beds with ornamental fishes in different concentrations. At the same time, a set of plants were raised in pots under a greenhouse set-up. The studied parameters were morphological (total weight and leaf number, shoot and root length, number of branches), biochemical (chlorophyll a, chlorophyll b, total chlorophyll, anthocyanin, xanthophyll, protein, and phenol contents) and antioxidant levels (Ascorbic acid and tocopherol). For analyzing the stress effects …

Effect Of Natural Elicitors And Cold Storageperiod On Quality Improvement Of Uae Date Palm Fruit (Phoenix Dactylifera L. Cv. Khesab), Shamsa Salem Nasser Abdulla Alblooshi

Theses

Date palm (Phoenix dactylifera L.) is one of the most important fruit trees grown in arid and semi-arid regions. Despite the immense capabilities of date palm, it is still a challenge to maintain fruit quality, marketability, and shelf life. The objective of this study was to investigate the synergistic effect of a preharvest spray application of the natural elicitor chitosan (Ch) 1% alone and in combination with salicylic acid (SA) 2 mM and calcium chloride (Ca) 3%; (Ch, SA, Ca, Ch+Ca, Ch+ SA, Ch+ SA +Ca) on the quality parameters, shelf life and bioactive compound content of date fruit of …

Mineral Nutritional Status Of Plants Of A Public Park Under Long-Term Irrigation With Treated Sewage Effluent, Chandana Chakraborty

Theses

Treated sewage water is widely used for irrigation of urban greenery in UAE, and it contains significant number of elements that serve as nutrients for plants. The crucial unresolved question that remains, is regarding its long-term impact on the nutritional status of plants. Sulaimi Park of Al Ain was chosen as the study site. The main objective was to examine if the nutrient supply was adequate for plants. N, P, K levels were expected to exceed plant demands and micronutrient supply was assumed to be below plant requirements. To assess this, soil pH, annual nutrients input with water and elemental …

Investigating The Role Of Fun30, A Chromatin Remodeler, In Dna Repair, Mehwish Iqbal

Dissertations

The repair of DNA double-strand breaks (DSBs) is crucial for maintaining genome stability. DSB repair needs to take place within the complex organization of the chromatin, and this requires changes in the chromatin structure adjacent to DSB sites. These changes occur through covalent histone modifications that alter histone-DNA contacts as well as by the action of ATP-dependent chromatin remodelers. Many chromatin remodelers, including Fun30, are involved in DSB repair. Fun30 facilitates DNA end resection at DSB site during the homologous recombination repair pathway. Apart from its role in DNA repair, Fun30 promotes gene silencing at heterochromatic loci such as telomeres, …

Elucidation Of The Interaction Between Hemorphins And Targets In The Renin-Angiotensin System, Amie Jobe

Theses

Hemorphins, short bioactive peptides produced by the enzymatic cleavage of the hemoglobin β-chain, exhibit anti-hypertensive effects via the inhibition of the angiotensin-1 converting enzyme (ACE1), a key component of the renin-angiotensin system (RAS) that governs blood pressure regulation. ACE1 and its homolog ACE2, which is also involved in the RAS, share significant similarity in their catalytic domains. The main objective of this work was to identify and compare the molecular mechanisms that underlie the interaction of hemorphins of camels and that of other mammals with ACE1 and ACE2. In silico docking and molecular dynamics simulations were employed, and in vitro …

Investigating The Presence Of Cladocera Species Within The Wetlands Of Uae, Shamma Eisa Salem Shahdad Alneyadi

Theses

The wetlands ecosystems found in the Arabian Peninsula have been poorly investigated. Moreover, the available information about the presence of freshwater communities have been rarely documented. Although there are scattered records about the presence of freshwater Cladocera organisms within the Arabian Gulf countries; few of them have received proper taxonomic identification. Cladocera populations in freshwater bodies are always characterizing its water quality and other living invertebrates’ community. United Arab Emirates wetlands are among the ecosystems belonging to Ramsar convention for its conservation. The presence of both temporary and permanent freshwater area has been developed after the great interest to collect …

Climate Change Awareness In The United Arab Emirates, Mariam Matar Abdulla Mohammed Almheiri

Theses

Climate change has focused public attention in the United Arab Emirates (UAE) on the role of society in environmental protection. The objective of this study was to determine the level of public awareness of climate change in the seven emirates of the UAE. The study also aimed to determine the spatial and geographical distribution and gender differences, as well as to investigate the possible influence of human activities on climate change impacts. In a cross-sectional survey, the researcher used a questionnaire to collect data from a sample of 4000 participants to answer the research questions. The drop-off pick-up (DOPU) method …

Response Of Five Chenopodium Quinoa Varieties To Different Salinity Levels, Elevated Co₂ And Uvb, Saif Ali Matar Al Blooshi

Theses

Ecosystems have been affected by climate changes. Both agriculture and environmental changes are correlated with various features since climate change is the main cause of abiotic and biotic stress which affects crop plants. The climate changes and their severe impact on plant productivity showed great intensities due to the effects of abiotic stress. In the present investigation, five quinoa varieties viz KAUST- 05395/CHFN-68 (V1), KAUST-05398/PI-614889 (V2), KAUST-05397/PI-614885 (V3), KAUST-05403/ICBA-Q3 (V4), and KAUST-05399/PI-614888 (V5) were screened for their salinity stress response by measuring the morphological parameters such as total plant height, fresh and dry weight of shoot and roots. V4 and …

Abiotic Stress Effect On Growth And Photosynthetic Characteristics In Emirati Date Palm Varieties, Nasser Abdullah Ghdayer Al Kaabi

Theses

Plants are naturally exposed to various environmental stresses that affect their growth and development. As a desert plant, date palm has developed strategies to protect itself from most abiotic stresses. However, projected climate changes and the interaction between the various abiotic stressors will have profound effects on date palm adaptation and production. In the present study, five date palm cultivars, namely Chichi, Kalas, Nabt Saif, Sultana and Zamli, were initially evaluated for salinity tolerance by measuring the growth parameters such as plant height, fresh weight and dry weight of shoots and roots. Based on the obtained results, Sultana and Zamli …

Studying Neurotoxic Effects Of Three Synthetic Insecticides And Two Herbal Infusions On The Nervous System Of The Fruit Fly Drosophila Melanogaster, Sara Khamis Obaid Hamarain Al Dhaheri

Theses

Pesticides applied on plants and animals can reach the human diet once they enter food chains. Insecticides are neurotoxic agents; they have the potential of causing damage to the nervous system in people. The damage could induce or promote neurodegenerative diseases such as the Parkinson’s and Alzheimer's. It is well-documented that the exposure to the insecticide chlorpyrifos (CPF) stimulate the Parkinson disease in humans and experimental animals. Thus, this research project will study effect of three synthetic insecticides pirimicarb, tefluthrin, and CPF on the nervous system of Drosophila melanogaster as a model organism. In addition, the project will evaluate the …

Livestock Ticks In The Uae: Prevalence, Distribution, Population Dynamics, And Associated Microorganisms, Nighat Perveen

Dissertations

Ticks are important vectors of an array of viral, bacterial, and protozoan pathogens resulting in a wide range of animal and human diseases in the Middle East and North Africa (MENA). In this study, ticks were collected from camels, cows, sheep, and goats in Abu Dhabi, Dubai, and Sharjah in the United Arab Emirates (UAE). The objectives of the study were to (1) identify tick species of livestock through taxonomic keys and using molecular markers, and determine their prevalence and distribution in the UAE, (2) assess Hyalomma dromedarii seasonal population fluctuation over a year under common camel breeding and management …