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Dissecting The Entry Pathways Of Hepatitis C And Bovine Viral Diarrhea Viruses, Donna M. Tscherne
Dissecting The Entry Pathways Of Hepatitis C And Bovine Viral Diarrhea Viruses, Donna M. Tscherne
Student Theses and Dissertations
Hepatitis C virus (HCV) and bovine viral diarrhea virus (BVDV) are closely related members of the family Flaviviridae and are important human and animal pathogens, respectively. In this work, I investigated how these viruses interact with and enter both naïve and previously infected cells, specifically, the mechanisms of superinfection exclusion, the phenomenon by which previous viral infection prevents reinfection of the same cell, and the pathways of entry into target cells for these viruses. BVDV-acutely infected cells establish two blocks to superinfection, at the levels of virus entry and RNA replication. The former is mediated by the BVDV E2 protein, …
Dendritic Cells Mediate The Dual Effects Of Ifn Alpha/Beta In Hcv Immunity, Randy Longman
Dendritic Cells Mediate The Dual Effects Of Ifn Alpha/Beta In Hcv Immunity, Randy Longman
Student Theses and Dissertations
Hepatitis C virus (HCV) infects an estimated 170 million people and is responsible for considerable morbidity and mortality worldwide. Successful resolution of infection is achieved naturally in approximately 30% of infected individuals and correlates with a strong T cell response. Furthermore, treatment with interferon (IFN)a achieves sustained virologic response in approximately 50% of chronically infected individuals. Conventional dendritic cells (cDCs), as the most potent antigen presenting cells, and plasmacytoid DCs (pDCs), as the principal IFNa/|3 producing cells, serve as potential targets for both immune evasion and therapeutic strategies. In order to evaluate the effects of HCV on DC function, we …