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Full-Text Articles in Life Sciences
The Impact Of Host Factors On Retroviral Evolution And The Identification Of A Novel Receptor That Was Used By An Ancient Primate Retrovirus, Steven J. Soll
The Impact Of Host Factors On Retroviral Evolution And The Identification Of A Novel Receptor That Was Used By An Ancient Primate Retrovirus, Steven J. Soll
Student Theses and Dissertations
The resurrection of inactive endogenous retroviruses allows us to learn about interactions between extinct pathogens and their hosts that occurred millions of years ago. Two of these paleoviruses, chimpanzee endogenous retrovirus 1 and 2 (CERV1 and CERV2), are relatives of modern murine leukemia viruses that are found in the genomes of a variety of old world primates, but are absent from the human genome. The nonexistence of human CERV1 and CERV2 homologues is peculiar given the numerous apparent cross-species transmissions that occurred between ancestors of old world monkeys, gorillas, and chimpanzees. It is possible that antiviral proteins were able to …
Dissecting The Contribution Of The Carboxyl-Terminal Domain And Tail Of Hiv-1 Integrase To Viral Dynamics And Enzymatic Function, Kevin Dominic Mohammed
Dissecting The Contribution Of The Carboxyl-Terminal Domain And Tail Of Hiv-1 Integrase To Viral Dynamics And Enzymatic Function, Kevin Dominic Mohammed
Student Theses and Dissertations
The Human Immunodeficiency Virus Type-1 (HIV-1) is the causative agent of the Acquired Immune Deficiency Syndrome (AIDS). Combination antiviral therapy has proven to be particularly effective at suppressing viral replication, yet complete eradication of the virus from an infected individual remains elusive. Recently, a new class of antiviral drugs targeting the viral integrase (IN) has been added to the HAART (high active antiretroviral therapy) regimen. This novel drug class exerts its inhibitory effect by targeting one aspect of the dual-staged integration reaction. In contrast to the other two viral targets of HAART, the reverse transcriptase (RT) and protease (PR) enzymes, …
Reconstitution And Characterization Of Human Endogenous Retrovirus-K, Young Nam Lee
Reconstitution And Characterization Of Human Endogenous Retrovirus-K, Young Nam Lee
Student Theses and Dissertations
Retroviruses are a family of clinically significant and scientifically fascinating viruses that infect a wide array of organisms from all vertebrate classes. The two hallmark events in the life cycle of retroviruses are the reverse transcription of the single stranded RNA (ssRNA) genome generating a double stranded DNA (dsDNA) and the integration of this dsDNA into the host genome. Because integration is irreversible and the infected cells are usually difficult to target for elimination in the host, the infection is generally permanent. HIV-1, the most important and well-studied member of all retroviruses, is the causative agent of acquired immune deficiency …