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Genetic And Biochemical Analyses Of The Flaviviridae Capsid Proteins, Catherine Lucy Murray
Genetic And Biochemical Analyses Of The Flaviviridae Capsid Proteins, Catherine Lucy Murray
Student Theses and Dissertations
The small, enveloped viruses of the family Flaviviridae are etiological agents of numerous important human and agricultural diseases including hepatitis C, yellow fever, and bovine viral diarrhea. Efficient dissemination of these viruses is dependent on the production of infectious particles, thought to arise by budding of the capsid protein and associated genomic RNA through a host cell-derived lipid membrane outfitted with envelope glycoproteins. The process of virion morphogenesis is not well understood, but the presumed involvement of numerous viral and cellular components makes it an attractive target for novel therapeutic drug design. To investigate the early events of Flaviviridae particle …
Dissecting The Entry Pathways Of Hepatitis C And Bovine Viral Diarrhea Viruses, Donna M. Tscherne
Dissecting The Entry Pathways Of Hepatitis C And Bovine Viral Diarrhea Viruses, Donna M. Tscherne
Student Theses and Dissertations
Hepatitis C virus (HCV) and bovine viral diarrhea virus (BVDV) are closely related members of the family Flaviviridae and are important human and animal pathogens, respectively. In this work, I investigated how these viruses interact with and enter both naïve and previously infected cells, specifically, the mechanisms of superinfection exclusion, the phenomenon by which previous viral infection prevents reinfection of the same cell, and the pathways of entry into target cells for these viruses. BVDV-acutely infected cells establish two blocks to superinfection, at the levels of virus entry and RNA replication. The former is mediated by the BVDV E2 protein, …