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Full-Text Articles in Life Sciences
Variability And Dynamics Of Apoptotic Events In Single Cells, Patrick Bhola
Variability And Dynamics Of Apoptotic Events In Single Cells, Patrick Bhola
Student Theses and Dissertations
Apoptosis is a form of programmed cell death that is necessary for development and organism homeostasis. The early stages of apoptosis are marked by the permeabilization of the mitochondrial outer membrane, the release of cytochrome c and Smac from mitochondria, and the activation of the caspase family of proteases. The permeabilization of the mitochondria outer membrane is thought to represent the commitment of a cell to an apoptotic fate, and the subsequent release of mitochondrial proteins is an “all or none†phenomenon that is completed in an individual cell within minutes. Although the cellular decision to commit to apoptosis is …
Genetic And Molecular Characterization Of Programmed Cell Death In The C.Elegans Tail-Spike Cell, Carine Waase-Maurer
Genetic And Molecular Characterization Of Programmed Cell Death In The C.Elegans Tail-Spike Cell, Carine Waase-Maurer
Student Theses and Dissertations
Work in Caenorhabditis elegans has been instrumental in deciphering the molecular basis of programmed cell death. However, despite extensive characterization of broadacting cell death genes, the molecular events triggering cell-specific activation of the cell death machinery remain, for the most part, unknown. In some C. elegans somatic cells, transcription of the egl-1 /BH3-only gene is believed to promoted cell-specific death. EGL-1 protein inhibits the CED-9/Bcl-2 protein, resulting in release of the caspase activator CED-4/Apaf-1. Subsequent activation of CED-3 caspase by CED-4 leads to cell death. But despite the important role of egl-1 transcription in promoting CED-3 activity in cells destined …