Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Life Sciences
Genetic And Molecular Characterization Of Programmed Cell Death In The C.Elegans Tail-Spike Cell, Carine Waase-Maurer
Genetic And Molecular Characterization Of Programmed Cell Death In The C.Elegans Tail-Spike Cell, Carine Waase-Maurer
Student Theses and Dissertations
Work in Caenorhabditis elegans has been instrumental in deciphering the molecular basis of programmed cell death. However, despite extensive characterization of broadacting cell death genes, the molecular events triggering cell-specific activation of the cell death machinery remain, for the most part, unknown. In some C. elegans somatic cells, transcription of the egl-1 /BH3-only gene is believed to promoted cell-specific death. EGL-1 protein inhibits the CED-9/Bcl-2 protein, resulting in release of the caspase activator CED-4/Apaf-1. Subsequent activation of CED-3 caspase by CED-4 leads to cell death. But despite the important role of egl-1 transcription in promoting CED-3 activity in cells destined …
The Roles Of Daf-6 And Cell-Cell Interactions In Sensory Organ Morphogenesis, Elliot A. Perens
The Roles Of Daf-6 And Cell-Cell Interactions In Sensory Organ Morphogenesis, Elliot A. Perens
Student Theses and Dissertations
The development of multicellular organs depends on the regulation of cell shape, position, and orientation. The genetic regulation of these morphogenetic processes is poorly understood. As a model for organ morphogenesis, I studied the development of the Caenorhabditis elegans amphid sensory organ. Sensory organs in diverse species are often composed of neuronal sensory endings accommodated in a lumen formed by ensheathing epithelia or glia. The generation of this structure may require cell-autonomous factors that control lumen formation, as well as cell non-autonomous factors that coordinate the morphogenesis of the lumen with the resident neuronal processes. Understanding these processes would provide …