Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Life Sciences
Structural And Functional Characterization Of B. Anthracis Udp-Glcnac 2-Epimerase And Salmonella Secreted Effector I, Shyam Bhaskaran
Structural And Functional Characterization Of B. Anthracis Udp-Glcnac 2-Epimerase And Salmonella Secreted Effector I, Shyam Bhaskaran
Student Theses and Dissertations
Structural biology has been an exceptionally powerful tool in the study of bacterial pathogenesis, not only in elucidating the molecular basis of disease as the first step towards the design of therapeutics but also in many cases leading to insights into hostpathogen biology that would not have been possible otherwise (Remaut & Waksman 2004). In this work such an approach has been taken towards the study of the Bacillus anthracis cell-wall enzyme UDP-GlcNAc 2-Epimerase and the Salmonella secreted virulence effector SseI. UDP-GlcNAc 2-Epimerase is an essential B. anthracis enzyme required for formation of the peptidoglycan cell wall precursor UDP-ManAc. We …
Exosporium Morphogenesis In Bacillus Cereus And Bacillus Anthracis, Monica Maria Fazzini Bellinzona
Exosporium Morphogenesis In Bacillus Cereus And Bacillus Anthracis, Monica Maria Fazzini Bellinzona
Student Theses and Dissertations
"Bacillus cereus is a Gram-positive spore-forming bacteria that can cause food poisoning and its close relative, Bacillus anthracis is the etiological agent of anthrax. In both cases, the spore, a differentiated cell type in a dormant state, starts the infection process. Thus, the exosporium, which constitutes the surface of the spore, plays an important role during natural infection of both B. cereus and B. anthracis. Proteins from the exosporium of B. cereus ATCC 4342, a B. anthracis-like strain, were extracted with 2% β-mercaptoethanol under alkaline conditions and identified by liquid chromatography coupled with tandem mass spectrometry. A novel cell surface …