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Full-Text Articles in Life Sciences
Studies On The Histone Methyltransferase G9a, Srihari Cidambi Sampath
Studies On The Histone Methyltransferase G9a, Srihari Cidambi Sampath
Student Theses and Dissertations
The size and complexity of eukaryotic genomes require that specific mechanisms exist for ensuring both the stability as well as the accessibility of DNA. One such mechanism is the association of DNA with histones to form chromatin, the physiological substrate of gene expression. An important means by which histones impact transcriptional activity is through site-specific enzymatic modification of the amino terminal histone “tailsâ€, which can alter the spectrum of chromatin-associated proteins and hence transcriptional states. Among the known modifications of histones, lysine methylation has been proposed to represent a relatively stable mark which might mediate stable activation or repression, depending …
The Dual Role Of Oca-B In B Cell Development And Signaling, Rachael Siegel
The Dual Role Of Oca-B In B Cell Development And Signaling, Rachael Siegel
Student Theses and Dissertations
OCA-B (Oct coactivator from B cells) is a B-cell specific coactivator of transcription that acts in conjunction with the ubiquitously expressed activator, OCT-1 or the B cell-restricted OCT-2. OCT-1 or OCT-2 can bind an upstream octamer element with the consensus sequence 5'- ATGCAAAT-3' in target gene promoters and enhancers. At the octamer element, the OCT-1/2-OCA-B complex is able to regulate gene expression via interaction with the basal transcription machinery. OCA-B was originally identified as a nuclear transcriptional coactivator and then shown to be essential for antigen-driven immune responses, including secondary isotype expression, germinal center formation and BCRdependent proliferation. These defects …