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Full-Text Articles in Life Sciences
Dre-1/Fbxo11, A Conserved F Box Protein, Regulates Apoptosis In C. Elegans And Is Mutated In Human Lymphoma, Michael Chiorazzi
Dre-1/Fbxo11, A Conserved F Box Protein, Regulates Apoptosis In C. Elegans And Is Mutated In Human Lymphoma, Michael Chiorazzi
Student Theses and Dissertations
In the course of metazoan embryonic and post-embryonic development, more cells are generated than exist in the mature organism, and these cells are deleted by the process of programmed cell death. In addition, cells can be pushed toward death when they accumulate genetic errors, are virally-infected or are otherwise deemed potentially-harmful to the overall organism. Caenorhabditis elegans has proved to be an excellent model system for elucidating the genetic underpinnings of cell death, and research has shown that the core machinery, made up of the egl-1, ced-9, ced-4 and ced-3 genes, is conserved across metazoans, and their homologues are crucial …
Mechanisms Of Controlled Proteolysis During Drosophila Spermatogenesis: Coordinate Action Of Apoptotic Caspases And The Ubiquitin-Proteasome System, Maya Bader
Student Theses and Dissertations
The regulation of apoptosis, or programmed cell death has been the subject of a vast body of research because of its implication in normal development, tissue homeostasis and a wide range of diseases. The major point of focus for understanding apoptosis regulation is the activation of its primary executioner: the caspase. This family of proteolytic enzymes has been shown to be tightly controlled, as many different proteins govern their transcription, stability, activation, and activity. Consequently, caspase regulation is extremely complex, and is further complicated by a discrepancy between different cell types and paradigms. Caspases have also been shown to have …
Cell Death Mechanisms In Drosophila Differentiated Photoreceptor Neurons, Alexis Robert Gambis
Cell Death Mechanisms In Drosophila Differentiated Photoreceptor Neurons, Alexis Robert Gambis
Student Theses and Dissertations
Apoptosis, or programmed cell death, is a form of physiological cell death that is essential for normal development and homeostasis. At the end of pupal development of the Drosophila retina, cell death terminates and photoreceptor neurons complete their differentiation process. We use these terminally differentiated photoreceptor neurons as a system to study neurodegeneration. We first adapt and develop fluorescent tools for photoreceptor visualization in vivo. These tools enable a recessive genetic screen to search for genes required for the survival of differentiated photoreceptors. Many redox and mitochondrial genes were found to protect photoreceptors from late cell death. Here, we focus …