Life Sciences Commons^™

Haplotype-Based Association Studies: Approaches To Current Challenges, Mark A. Levenstien

Student Theses and Dissertations

Haplotype-based association studies have greatly aided researchers in their attempts to map genes. However, current designs of haplotype-based association studies lead to several challenges from a statistical perspective. To reduce the number of variants, some researchers have employed hierarchical clustering. This thesis starts by addressing the multiple testing problem that results from applying a hierarchical clustering procedure to haplotypes and then performing a statistical test for association at each of the steps in the resulting hierarchy. Applying our method to a haplotype case-control dataset, we find a global p-value. Relative to the minimum p-value over all steps in the hierarchy, …