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From Naturally Occurring Tumor Immunity To Supernatural T Cells: Isolation And Characterization Of A Murine T Cell Receptor Specific For Human Breast And Ovarian Tumor Antigen Cdr2, Bianca D. Santomasso
From Naturally Occurring Tumor Immunity To Supernatural T Cells: Isolation And Characterization Of A Murine T Cell Receptor Specific For Human Breast And Ovarian Tumor Antigen Cdr2, Bianca D. Santomasso
Student Theses and Dissertations
Patients with paraneoplastic cerebellar degeneration (PCD), a form of neuronal autoimmunity, have a co-occurring natural immune response against a protein called cdr2 in their breast and ovarian carcinomas, and thus provide an innovative starting point for understanding how to harness the immune system to fight cancer. We previously demonstrated cdr2-specific cytotoxic T lymphocytes (CTL) in the peripheral blood of HLA-A2.1+ PCD patients, suggesting that CTLs mediate tumor immunity in these patients. Cdr2 is expressed by a large proportion of breast and ovarian tumors from individuals who do not develop neurological disease, suggesting that immune responses to this antigen may develop …