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Theses/Dissertations

Rockefeller University

1973

Articles 1 - 6 of 6

Full-Text Articles in Life Sciences

Studies On The Secretory Process Of Rabbit Parotid, John David Castle Jan 1973

Studies On The Secretory Process Of Rabbit Parotid, John David Castle

Student Theses and Dissertations

An in vitro incubation system which allows the labeling and isolation of secretion granules - and their subsequent resolution into membrane and content subfractions - has been developed by using dissected lobules of rabbit parotid glands. The system can be used to study a series of aspects related to the last phases of the secretory cycle (concentration, storage, discharge). The work reported in this thesis characterizes the system and presents data concerning the relative rates of synthesis of membrane and content proteins.


Studies On The Inheritance Of Idiotypic Markers Of Mouse Antibody To Streptococcal Group A Carbohydrate And On Other Genetic Factors Which Influence The Immune Response, David Elwood Briles Jan 1973

Studies On The Inheritance Of Idiotypic Markers Of Mouse Antibody To Streptococcal Group A Carbohydrate And On Other Genetic Factors Which Influence The Immune Response, David Elwood Briles

Student Theses and Dissertations

The antibody response to Group A streptococcal carbohydrate was measured in 10 inbred mouse strains after immunization with whole heatkilled streptococcal vaccine. Using A/J and SWR/J mice, dose response studies were performed to determine optimai immunization conditions of dose, route of injection, and age of mice. In the course of these studies, inbred strains were identified which produced high and low levels of anti-Group A antibody after immunization with Group A vaccine. Subsequent genetic experiments demonstrated that the differences in antibody titer observed among some of these strains were under the genetic control of genes at several loci. When A/J …


Short-Term Memory For Temporal And Spatial Order Information, Alice F. Healy Jan 1973

Short-Term Memory For Temporal And Spatial Order Information, Alice F. Healy

Student Theses and Dissertations

The present investigation includes theoretical and experimental comparisons of short-term memory for temporal and spatial order information. Two questions are of central interest: whether short-term memory for letter sequences is limited to a verbal-acoustic coding process and whether the loss of information from short-term memory results from interference or from a mere decay with time. The basic experimental paradigm employed in the present study was the Brown-Peterson design. The items to be recalled were sequences of four consonants presented visually in varying temporal and spatial arrangements. On each trial the to-be-remembered sequence of consonants was followed by an intervening task …


Rigorous Bounds On Strong Interaction Coupling Constants, James Bruce Healy Jan 1973

Rigorous Bounds On Strong Interaction Coupling Constants, James Bruce Healy

Student Theses and Dissertations

We investigate the problem of deriving bounds on strong interaction scattering amplitudes from the results of axiomatic field theory.


Effects Of Ventromedial Hypothalamic Lesions On Food-Reinforced Fixed Ratio Responding, Ronald Paul Larkin Jan 1973

Effects Of Ventromedial Hypothalamic Lesions On Food-Reinforced Fixed Ratio Responding, Ronald Paul Larkin

Student Theses and Dissertations

Previous research has shown that rats with experimental lesions in the ventromedial area of the hypothalamus become obese due to hyperphagia. This striking effect on ad libitum food intake is sometimes accompanied by an increase and sometimes by a decrease in other measures of propensity to eat such as food-rewarded lever pressing. The current experiments attempt to discover the conditions under which these opposite effects on "food-motivated" behavior occur. Rats with ventromedial lesions made with steel electrodes showed a decrease relative to controls in lever pressing on a fixed ratio schedule. This effect was also seen in rats which had …


Rapid Alterations In Rat Brain Tryptophan Hydroxylase Activity; Effects Of Adrenal Steroids, Drugs And Stressors, Efrain Charles Azmitia Jr. Jan 1973

Rapid Alterations In Rat Brain Tryptophan Hydroxylase Activity; Effects Of Adrenal Steroids, Drugs And Stressors, Efrain Charles Azmitia Jr.

Student Theses and Dissertations

Tryptophan (TP) hydroxylase activity was measured using a modification of the method developed by Ichiyama et al. (l968). The distribution of the enzyme in the rat brain was determined and found to correlate with serotonin (5-HT) distribution. Bilateral adrenalectomy resulted in a decrease enzyme activity in most areas examined with the largest drop occurring in the midbrain. A similar decrease was found in 5-HT in vivo turnover. Injection of corticosterone led to an increase both in normal and adrenalectomized rats. This increase was blocked by cycloheximide, a protein synthesis inhibitor. The midbrain enzyme activity was increased in normal rats by …