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Reprogramming Of Rat Hepatoma Cells With Fibroblast-Specific Protein Twist1, Kezban Ucar Cifci
Reprogramming Of Rat Hepatoma Cells With Fibroblast-Specific Protein Twist1, Kezban Ucar Cifci
Masters Theses
In mammalian development, a complex system comprised of regulatory signals causes tissue distinction with unique structures as well as functions. Gene expression controls these functions through specific combinations of transcription factors and cofactors that influence cell differentiation by both activation and repression of genes.
Whole genome microarray studies of fibroblasts have identified candidate genes that can serve as master regulators of fibroblast identity. A previous study showed that Prrx1 and Snai2 play important roles in activating expression of fibroblast identity, and Snai2 overexpression in hepatoma cells (Fg14) activated expression of fibroblast specific genes. Moreover, Snai2 overexpression resulted in repression of …