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Life Sciences Commons

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Theses/Dissertations

Eastern Illinois University

Pharmacology, Toxicology and Environmental Health

2014

Articles 1 - 2 of 2

Full-Text Articles in Life Sciences

Wastewater Influent And Effluent Concentrations Of 17 Beta-Estradiol: A Study Of The Influence Of A University Community And The Risk To Environmental Health, Kyle Heffron Jan 2014

Wastewater Influent And Effluent Concentrations Of 17 Beta-Estradiol: A Study Of The Influence Of A University Community And The Risk To Environmental Health, Kyle Heffron

Masters Theses

The concentration of 17β-estradiol (E2) was measured through stages of wastewater treatment at a central Illinois wastewater treatment plant (WWTP). E2 concentration was quantified using a competitive enzyme linked immunosorbent assay (ELISA). The concentration of E2 was compared with demographic effects of a university, physical parameters of the wastewater (dissolved oxygen, pH, and temperature) and daily influent and effluent flow rates. Effluent concentrations ranged from 0 to 25.3 ng L-1 with an average discharge of 3.6 ng L-1. E2 concentration was shown to increase at the start of each university semester, however, this trend was not observed …


The Effects Of 1, 3, & 7 Trisubstituted And 8-Cyclopentyl Alkylxanthines On Respiration In Newborn Rats, Nathan Creel Davidson Jan 2014

The Effects Of 1, 3, & 7 Trisubstituted And 8-Cyclopentyl Alkylxanthines On Respiration In Newborn Rats, Nathan Creel Davidson

Masters Theses

Methylxanthines have been shown to be promising respiratory stimulants in newborns suffering from recurrent apnea. The respiratory stimulant effects of methylxanthines are most likely due to their antagonism of adenosine receptors. These drugs have been shown to stimulate respiration in newborn rats in doses in excess of 10 mg/kg body weight. Structure-activity studies have shown that methylxanthines not only differ in the antagonism of A1 and A2 adenosine receptors but also, as a consequence of their different chemical structures, differ in potency as respiratory stimulants. To assess this, two potent A1 adenosine receptor antagonists, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) and …