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Full-Text Articles in Life Sciences
The Determination Of Lead In Blood By Electrothermal Atomization Atomic Absorption Spectrometry : Method Improvements And Clinical Fitness For Purpose For Detecting Elevated Blood Lead Levels, Emily Jean Pacer
Legacy Theses & Dissertations (2009 - 2024)
Lead (Pb) is ubiquitous in the environment and exposure can have adverse health effects even at low concentrations, particularly in young children. Blood lead levels (BLLs) are the best indicator of recent Pb exposure. Based upon data from the NHANES, the Centers for Disease Control and Prevention’s (CDC) blood Pb (BPb) reference value, defined as the 97.5th percentile of children 1-5 years old, was lowered from 10 μg/dL to 5 μg/dL in 2012. According to more recent NHANES data, the 97.5th percentile has decreased to 3.5 μg/dL. If the CDC recommends a further lowering of the BPb reference value, many …
Accumulation And Spatial Distribution Of Lead And Other Trace Elements In Keratinized Tissues : Investigations Based On Analytical Atomic Spectrometry, Mina W. Tehrani
Accumulation And Spatial Distribution Of Lead And Other Trace Elements In Keratinized Tissues : Investigations Based On Analytical Atomic Spectrometry, Mina W. Tehrani
Legacy Theses & Dissertations (2009 - 2024)
Human biomonitoring for toxic metals such as lead (Pb) provides information about absorbed dose from all exposure routes, and is critical for identifying exposed individuals and assessing health risks. Blood Pb and bone Pb are the primary validated biomarkers for assessing short-term and historical Pb exposures, respectively, while non-traditional matrices, including keratinized tissues, can provide complementary exposure information. Hard keratinized tissues – including hair, nails, hooves, and horns – grow incrementally, potentially preserving chemical exposure histories over a span of days to years. Analytical limitations and poor interlaboratory reproducibility, however, have led to debate around the use of human nails …
Consequences Of Developmental Lead (Pb2+) Exposure On Reproductive Strategies In Drosophila, Elizabeth Kathleen Peterson
Consequences Of Developmental Lead (Pb2+) Exposure On Reproductive Strategies In Drosophila, Elizabeth Kathleen Peterson
Legacy Theses & Dissertations (2009 - 2024)
Anthropogenic lead (Pb) pollution is ubiquitous in the environment and a risk factor for both human and wildlife health. Pb exposure has the potential to alter reproductive strategies with respect to mate choice and reproductive output. This could be especially deleterious if these changes disrupt adaptive behavioral and reproductive life history strategies. Therefore, the overall aim of this body of work was to examine the consequences of developmental Pb exposure on reproductive strategies, using Drosophila melanogaster as a model system. In all experiments, D. melanogaster were reared from egg stage to adulthood in either control or leaded medium and were …
An Investigation Of The Uptake, Distribution, And Accumulation Of Lead And Other Trace Elements In Caprine Brain Tissues Using Analytical Atomic Spectrometry, Amy Joanna Steuerwald
An Investigation Of The Uptake, Distribution, And Accumulation Of Lead And Other Trace Elements In Caprine Brain Tissues Using Analytical Atomic Spectrometry, Amy Joanna Steuerwald
Legacy Theses & Dissertations (2009 - 2024)
Exposure to toxic elements and dysregulation of essential elements have been implicated in neurodegenerative disorders. Despite the importance of trace elements in neurological function, little is known regarding their uptake and distribution within brain tissues. Even less is known regarding the impact of toxic metal exposure (i.e., Pb) on endogenous metals within the brain.