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Theses/Dissertations

Pharmacology, Toxicology and Environmental Health

Old Dominion University

Drug abuse in pregnancy dx research

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The Effect Of Illicit Drugs On The Cardiovascular And Hormonal Responses In Pregnant Rabbits, Andrea Alana Chambliss Apr 1999

The Effect Of Illicit Drugs On The Cardiovascular And Hormonal Responses In Pregnant Rabbits, Andrea Alana Chambliss

Biological Sciences Theses & Dissertations

The purpose of this study is to determine the effect of acute administration of heroin and ecgonine methyl ester (EME) on renin and atrial natriuretic peptide (ANP) secretion in time dated New Zealand White rabbits. Thirteen rabbits were studied. Arterial blood pressure and pCOz, increased significantly from a control value of 80 ± 8 mmHg and 30 ± 2 mmHg respectively to 93 ± 18 mmHg and 31 ± 1 mmHg. pO2 decreased from 99 ± 8 mmHg to 90 ± 11 mmHg 10 minutes after heroin administration. EME caused arterial blood pressure to significantly increase from a control …

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