Life Sciences Commons^™

St John's Wort Drug Interactions, Hans Wohlmuth

Dr Hans Wohlmuth

No abstract provided.

The Spring Migration Of Raptors In Southern Israel And Sinai, S Christensen, O Lou, M Miller, Hans Wohlmuth

Dr Hans Wohlmuth

No abstract provided.

Bush Medicines Of Western Sydney, Hans Wohlmuth

Dr Hans Wohlmuth

The knowledge of traditional Aboriginal use of medicinal plants in the Sydney area is almost non-existent. A number of plants growing in Mitchell Park, northwest of Sydney, are discussed in terms of their potential medicinal use by the traditional owners of the area. In the absence of records of medicinal plant use in the area, the discussion draws upon information from other areas of Australia. Aboriginal health prior to European settlement is also briefly discussed in an attempt to identify some of the ailments Aboriginal people may have found themselves treating with bush medicines. It is concluded that the area …

Pharmacognosy – Is It Really Relevant?, Hans Wohlmuth

Dr Hans Wohlmuth

No abstract provided.

On Standardised Extracts, Hans Wohlmuth

Dr Hans Wohlmuth

The author discusses the use of standardised extracts versus non- standardised extracts and addresses several issues raised in an earlier paper which he asserts contained grossly inaccurate information, incorrect assertions and insinuations about standardised extracts.

What Are Aflatoxins?, Hans Wohlmuth

Dr Hans Wohlmuth

Aflatoxins are toxic secondary metabolites wh ich are rarely produced by species of mou Ids belonging to the genus Aspergillus. These moulds grow on stored plant foods, in particular peanuts, wheat and corn. In tropical countries an estimated 25% or more of the food may be contaminated with aflatoxins (Raven et al 1992).

Herbal Medicines- An Ethnobotanical Survey, Hans Wohlmuth

Dr Hans Wohlmuth

No abstract provided.

Biologically Active Dibenzofurans From Pilidiostigma Glabrum, An Endemic Australian Myrtaceae, Qing-Yao Shou, Linda Banbury, Dane Renshaw, Eleanore Lambley, Htwe Mon, Graham Macfarlane, Hans Griesser, Michael Heinrich, Hans Wohlmuth

Dr Hans Wohlmuth

In an effort to identify new anti-inflammatory and antibacterial agents with potential application in wound healing, five new dibenzofurans, 1,3,7,9-tetrahydroxy-2,8-dimethyl-4,6-di(2-methylbutanoyl)dibenzofuran (1), 1,3,7,9-tetrahydroxy-2,8-dimethyl-4-(2-methylbutanoyl)-6-(2-methylpropionyl)dibenzofuran (2), 1,3,7,9-tetrahydroxy-2,8-dimethyl-4,6-di(2-methylpropionyl)dibenzofuran (3), 1,3,7,9-tetrahydroxy-4,6-dimethyl-2-(2-methylbutanoyl)-8-(2-methylpropionyl)dibenzofuran (4), and 1,3,7,9-tetrahydroxy-4,6-dimethyl-2,8-di(2-methylpropionyl)dibenzofuran (5), were isolated from the leaves of Pilidiostigma glabrum together with one previously described dibenzofuran. Structure elucidation was achieved by way of spectroscopic measurements including 2D-NMR spectroscopy. Compounds with 2,8-acyl substitutions had potent antibacterial activity against several Gram-positive strains (MIC in the low micromolar range), while compounds with 4,6-acyl substitutions were less active. All compounds except 3 inhibited the synthesis of …

Factors Affecting Pharmacists Recommendation Of Complementary Medicines: A Qualitative Study Of Australian Pharmacists, Sarah Culverhouse, Hans Wohlmuth

Dr Hans Wohlmuth

Background

Complementary medicines (CMs) are widely used by the Australian public, and pharmacies are major suppliers of these medicines. The integration of CMs into pharmacy practice is well documented, but the behaviours of pharmacists in recommending CMs to customers are less well studied. This study reports on factors that influence whether or not pharmacists in Australia recommend CMs to their customers.

Methods

Data were collected from semi-structured interviews with twelve practicing pharmacists based in Brisbane, Australia. The qualitative data were analysed by thematic analysis.

Results

The primary driver of the recommendation of CMs was a desire to provide a health …

Genomics And Metabolomics For New Plant Products, Daniel Waters, Peter Bundock, Hans Wohlmuth, Myrna Deseo, Lei Liu, Frances Shapter, Agnelo Furtado

Dr Hans Wohlmuth

No abstract provided.

Chemical Constituents From Fritillaria Anhuiensis, Qing-Yao Shou, Hans Wohlmuth, X He, Lei Liu, Zhengwu Shen

Dr Hans Wohlmuth

Phytochemical investigation on Fritillaria anhuiensis led to the isolation of one new labdane diterpenoid (12) 14(RS),15-dihydroxy-8(17),12(E)-labdadien-19-oic-acid and 26 known compounds (1–11, 13–27). Their structures were determined on the basis of spectroscopic analysis and by comparison of their spectral data with those reported in the literature. Fourteen known compounds (4, 5, 7–11, 13, 14, 16, 17, 22–24) were isolated from F. anhuiensis for the first time, and five of them (10, 11, 13, 23, 24) are reported from the family Liliaceae for the first time. Some of the compounds identified in the present investigation may have chemotaxonomic value at the generic …

Chemical Composition And Antioxidant And Anticandidal Activities Of Essential Oils From Different Wild Moroccan Thymus Species, Chaima Jamali, Leila El Bouzidi, Khalid Bekkouche, Hassani Lahcen, Mohammed Markouk, Hans Wohlmuth, David Leach, Abdelaziz Abbad

Dr Hans Wohlmuth

Samples of the aerial parts of Thymus broussonetii, T. ciliatus, T. leptobotrys, T. maroccanus, T. pallidus, T. satureioides, and T. serpyllum collected from different natural regions in southern and south-western Morocco were analyzed for their qualitative and quantitative essential oil profiles. In total, 46 compounds, representing more than 99% of the oils, were characterized. Monoterpenes, both hydrocarbons (12.9–58.0%) and oxygenated monoterpenes (38.8–81.1%), were the principal classes of compounds for most of the thyme species studied. Cluster analysis allowed the classification of the species into three main groups: a carvacrol group (Group I), comprising the species T. maroccanus …

A Combined Phase I And Ii Open-Label Study On The Immunomodulatory Effects Of Seaweed Extract Nutrient Complex, Stephen Myers, Joan O'Connor, J Helen Fitton, Lyndon Brooks, Margaret Rolfe, Paul Connellan, Hans Wohlmuth, Phillip Cheras, Carol Morris

Dr Hans Wohlmuth

Background: Isolated fucoidans from brown marine algae have been shown to have a range of immune-modulating effects. This exploratory study aimed to determine whether a seaweed nutrient complex containing a blend of extracts from three different species of brown algae plus nutrients is safe to administer and has biological potential as an immune modulator. The study was undertaken as an open-label combined Phase I and II study. Methods: Participants (n = 10) were randomized to receive the study medication at either a 100 mg (n = 5) or 1000 mg (n = 5) dose over 4 weeks. The primary outcome …

An In Vitro Investigation Of Herbs Traditionally Used For Kidney And Urinary System Disorders: Potential Therapeutic And Toxic Effects, Ken Wojcikowski, Hans Wohlmuth, David Johnson, Margaret Rolfe, Glenda Gobe

Dr Hans Wohlmuth

Aim: Renal fibrosis is central to progression of most chronic renal pathologies. Antioxidants that protect the tubular epithelium and anti-fibrotics that induce apoptosis of pro-fibrotic myofibroblasts without adversely affecting tubular epithelium may slow progression of renal fibrosis, while toxic substances may exacerbate renal scarring. We investigated 47 herbs for their in vitro toxic or antioxidant effects on normal renal mammalian fibroblasts (NRK49F) and tubular epithelial cells (NRK52E) to determine their potential value as therapeutic agents in renal fibrosis involving oxidative stress. Methods: Herbs were chosen because of their traditional use in kidney or urinary system disorders, or because of recent …

Pharmacognosy And Medicinal Plant Pharmacology: A Student Manual, Hans Wohlmuth

Dr Hans Wohlmuth

No abstract provided.

Intraspecific Chemical Variability Of Essential Oil From Leaves Of Cupressus Atlantica Gaussen, An Endemic And Endangered Coniferous Species In Morocco, Abdelaziz Abbad, Youssef Sfairi, Hassani Lahcen, Khalid Bekkouche, Mohammed Markouk, Hans Wohlmuth, David Leach

Dr Hans Wohlmuth

The composition of essential oils isolated from leaves of 11 natural populations of Cupressus atlantica, an endemic and endangered coniferous species from Morocco, was investigated by GC-MS. In total, 42 essential oil components were identified, accounting for 73.1–97.7% of the total oil. Monoterpene (25.2–84.9%) and sesquiterpene hydrocarbons (12.2–46.8%) were the principal subclasses of compounds, with α-pinene (15–65.4%), germacrene D (5.9–30.5%), δ-3-carene (2–16.6%) and γ-cadinene (1.3–9.8%) as the main constituents. The results of the oil composition were analysed by hierarchical cluster and principal component analysis that established three main groups of essential oils. These oils were differentiated …