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Full-Text Articles in Life Sciences
Emerging Role Of Micrornas In Liver Diseases, Shashi Bala, Miguel Marcos, Gyongyi Szabo
Emerging Role Of Micrornas In Liver Diseases, Shashi Bala, Miguel Marcos, Gyongyi Szabo
Gyongyi Szabo
MicroRNAs are a class of small non-coding RNAs that are found in plants, animals, and some viruses. They modulate the gene function at the post-transcriptional level and act as a fine tuner of various processes, such as development, proliferation, cell signaling, and apoptosis. They are associated with different types and stages of cancer. Recent studies have shown the involvement of microRNAs in liver diseases caused by various factors, such as Hepatitis C, Hepatitis B, metabolic disorders, and by drug abuse. This review highlights the role of microRNAs in liver diseases and their potential use as therapeutic molecules.
In Vitro And In Vivo Models Of Acute Alcohol Exposure, Angela Dolganiuc, Gyongyi Szabo
In Vitro And In Vivo Models Of Acute Alcohol Exposure, Angela Dolganiuc, Gyongyi Szabo
Gyongyi Szabo
Alcohol abuse is a global problem due to the financial burden on society and the healthcare system. While the harmful health effects of chronic alcohol abuse are well established, more recent data suggest that acute alcohol consumption also affects human wellbeing. Thus, there is a need for research models in order to fully understand the effect of acute alcohol abuse on different body systems and organs. The present manuscript summarizes the interdisciplinary advantages and disadvantages of currently available human and non-human models of acute alcohol abuse, and identifies their suitability for biomedical research.