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Full-Text Articles in Life Sciences
On Characterizing Adaptive Events Unique To Modern Humans, Jessica Crisci, Alex Wong, Jeffrey Good, Jeffrey Jensen
On Characterizing Adaptive Events Unique To Modern Humans, Jessica Crisci, Alex Wong, Jeffrey Good, Jeffrey Jensen
Jessica L Crisci
Ever since the first draft of the human genome was completed in 2001 there has been increased interest in identifying genetic changes that are uniquely human, which could account for our distinct morphological and cognitive capabilities with respect to other apes. Recently, draft sequences of two extinct hominin genomes, a Neanderthal and Denisovan, have been released. These two genomes provide a much greater resolution to identify human-specific genetic differences than the chimpanzee, our closest extant relative. The Neanderthal genome paper presented a list of regions putatively targeted by positive selection around the time of the human-Neanderthal split. We here seek …
Recent Progress In Polymorphism-Based Population Genetic Inference., Jessica Crisci, Yu-Ping Poh, Angela Bean, Alfred Simkin, Jeffrey Jensen
Recent Progress In Polymorphism-Based Population Genetic Inference., Jessica Crisci, Yu-Ping Poh, Angela Bean, Alfred Simkin, Jeffrey Jensen
Jessica L Crisci
The recent availability of whole-genome sequencing data affords tremendous power for statistical inference. With this, there has been great interest in the development of polymorphism-based approaches for the estimation of population genetic parameters. These approaches seek to estimate, for example, recently fixed or sweeping beneficial mutations, the rate of recurrent positive selection, the distribution of selection coefficients, and the demographic history of the population. Yet despite estimating similar parameters using similar data sets, results between methodologies are far from consistent. We here summarize the current state of the field, compare existing approaches, and attempt to reconcile emerging discrepancies. We also …