Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
The Regulation Of Genes And Genomes By Small Rnas., Victor Ambros, Xuemei Chen
The Regulation Of Genes And Genomes By Small Rnas., Victor Ambros, Xuemei Chen
Victor R. Ambros
A recent Keystone Symposium on 'MicroRNAs and siRNAs: Biological Functions and Mechanisms' was organized by David Bartel and Shiv Grewal (and was held in conjunction with 'RNAi for Target Validation and as a Therapeutic', organized by Stephen Friend and John Maraganore). The 'MicroRNAs and siRNAs' meeting brought together scientists working on diverse biological aspects of small regulatory RNAs, including microRNAs, small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs and rasiRNAs). Among the themes discussed were the diversity of small regulatory RNAs and their developmental functions, their biogenesis, the identification of their regulatory targets, their mechanisms of action, and their roles …
Potent Effect Of Target Structure On Microrna Function, Peter Williams, Dang Long, Rosalind Lee, Chi Chan, Victor Ambros, Ye Ding
Potent Effect Of Target Structure On Microrna Function, Peter Williams, Dang Long, Rosalind Lee, Chi Chan, Victor Ambros, Ye Ding
Victor R. Ambros
MicroRNAs (miRNAs) are small noncoding RNAs that repress protein synthesis by binding to target messenger RNAs. We investigated the effect of target secondary structure on the efficacy of repression by miRNAs. Using structures predicted by the Sfold program, we model the interaction between an miRNA and a target as a two-step hybridization reaction: nucleation at an accessible target site followed by hybrid elongation to disrupt local target secondary structure and form the complete miRNA-target duplex. This model accurately accounts for the sensitivity to repression by let-7 of various mutant forms of the Caenorhabditis elegans lin-41 3' untranslated region and for …
The 2007 George W. Beadle Medal. Robert K. Herman., Victor Ambros
The 2007 George W. Beadle Medal. Robert K. Herman., Victor Ambros
Victor R. Ambros
No abstract provided.