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Articles 1 - 7 of 7
Full-Text Articles in Life Sciences
Diabetes Mellitus Affects Working Memory, Dylone C. Braganza, Emmanuel Flores, Lauren A. Crew, Ryan A. Wirt, Andrew A. Ortiz, Adam M. Mcneela, Jefferson W. Kinney, James M. Hyman
Diabetes Mellitus Affects Working Memory, Dylone C. Braganza, Emmanuel Flores, Lauren A. Crew, Ryan A. Wirt, Andrew A. Ortiz, Adam M. Mcneela, Jefferson W. Kinney, James M. Hyman
Spectra Undergraduate Research Journal
Alzheimer’s disease (AD) degrades the brain’s ability to remember, think, and carry out tasks. The exact cause is not known, but several risk factors have been identified, including diabetes mellitus (DM). DM causes elevated blood sugar levels due to reduced insulin production in the pancreas. The linkage between elevated glucose levels and the behavioral impairments are not fully understood, which was the focus of this study. Rats were trained to alternate directions in a maze to receive a reward on consecutive trials. After training, five rats were injected with streptozotocin (STZ), which induces hyperglycemia by injuring pancreatic beta cells. Three …
The Neurobiological Relationship Between Childhood Maltreatment And Major Depressive Disorder (Mdd), Morgan Clinton
The Neurobiological Relationship Between Childhood Maltreatment And Major Depressive Disorder (Mdd), Morgan Clinton
Global Tides
Childhood maltreatment compromises healthy development, impacts neurobiology, and is associated with lasting alterations to emotional perception, processing, and regulation. Most significantly, childhood maltreatment increases the risk for later development of emotional disorders such as major depressive disorder (MDD). The stress associated with both childhood maltreatment and MDD can lead to lasting alterations to the fronto-limbic circuitry. Using functional and structural magnetic resonance imaging, researchers have observed hippocampal atrophy and amygdala hyperresponsiveness in participants who’ve experienced both childhood maltreatment and MDD. Furthermore, researchers have also observed increased connectivity between the hippocampus and amygdala in victims of childhood maltreatment. Because childhood maltreatment …
The Effects Of Different Doses Of Diclofenac Sodium On Newborn Rat Hippocampus Exposed During The Third Trimester, Ebru Eli̇bol, Süleyman Kaplan, Gamze Altun, Abdurrahman Aksoy, Berri̇n Zuhal Altunkaynak
The Effects Of Different Doses Of Diclofenac Sodium On Newborn Rat Hippocampus Exposed During The Third Trimester, Ebru Eli̇bol, Süleyman Kaplan, Gamze Altun, Abdurrahman Aksoy, Berri̇n Zuhal Altunkaynak
Turkish Journal of Veterinary & Animal Sciences
The main aim of the present study was to examine the neurotoxic effects of prenatal exposure to varying doses of diclofenac sodium (DS) on the rat hippocampus. Twenty-eight Wistar albino adult female rats weighing 280-300 g were initially used for pregnancy. When vaginal plaques were seen in female rats, it was accepted as the 0th day of pregnancy. Female rats were divided into five main groups; pure control, saline, low dose DS (3.6 mg/kg), moderate dose DS (9 mg/kg), and high dose DS (18 mg/kg). They were exposed to these treatments during their gestation. After birth, all newborn male rats …
Effect Of Long-Term Physical Exercise On Blood Pressure In African Americans, Taunjah P. Bell, Katharine A. Mcintyre, Rosamary Hadley
Effect Of Long-Term Physical Exercise On Blood Pressure In African Americans, Taunjah P. Bell, Katharine A. Mcintyre, Rosamary Hadley
International Journal of Exercise Science
International Journal of Exercise Science 7(3) : 186-193, 2014. Long-term physical exercise has been shown to noticeably reduce blood pressure (BP) and remarkably attenuate symptoms of hypertension. It is believed that physical exercise induces these beneficial effects by increasing the blood supply to the brain, enhancing the release of growth factors from skeletal muscles into the bloodstream, facilitating neurogenesis, stimulating angiogenesis, and influencing endothelial cell proliferation and subsequent endothelial cell membrane permeability. Previous findings also revealed that physical exercise significantly elevates brain-derived neurotrophic factor (BDNF) concentrations which appear to increase dramatically in BP-sensing neurons during hypertension. Elevating BDNF levels is …
A Comparision Of The Right And Left Hippocampus In Therabbit Brain In Terms Of Cell Density, Hayri Genç
A Comparision Of The Right And Left Hippocampus In Therabbit Brain In Terms Of Cell Density, Hayri Genç
Turkish Journal of Biology
The aim of this study was to investigate the structural asymmetry between the hemispheres by comparing the number of pyramidal cells in the right dorsal hippocampus with left dorsal hippocampus in the rabbit brain. Six adult domestic New Zeland rabbits were used in experiments. All animals were perfused intracardially with neutral formaline (10 %) under deep aneasthesia. The serial frontal sections were stained with thionin. The rostro-caudal level of these sections were determined by using a stereotaxic atlas of the rabbit brain. The number of pyramidal neurons was determined by counting identifiable neurons which had distict nucleus and nucleolus. The …
Proton Microprobe And Particle Induced X-Ray Emission (Pixe) Analysis For Studies Of Pathological Brain Tissue, K. G. Malmqvist, A. Brun, K. Inamura, E. Martins, L. G. Salford, B. K. Siesjö, U. A. S. Tapper, K. Themner
Proton Microprobe And Particle Induced X-Ray Emission (Pixe) Analysis For Studies Of Pathological Brain Tissue, K. G. Malmqvist, A. Brun, K. Inamura, E. Martins, L. G. Salford, B. K. Siesjö, U. A. S. Tapper, K. Themner
Scanning Microscopy
Particle Indiced X-ray Emission and proton microprobe analyses have been applied for the investigation of regional elemental distributions in connection with various pathological states in the brain. Malignant brain tumours and adjacent histologically intact tissue removed during surgery were analysed with PIXE. Systematic elemental variations, e.g., for calcium and selenium, were observed in the tumour front. The proton microprobe was applied to study the Ca and K concentrations in various cell strata in hippocampus following transient ischaemia in rat brain. Significant increases in the Ca level occurred in selectively vulnerable cells within 48 h after the ischaemia.
The Effect Of High Energy (Hze) Particle Radiation (40ar) On Aging Parameters Of Mouse Hippocampus And Retina, D. E. Philpott, W. Sapp, J. Miquel, K. Kato, R. Corbett, J. Stevenson, S. Black, K. A. Lindseth, E. V. Benton
The Effect Of High Energy (Hze) Particle Radiation (40ar) On Aging Parameters Of Mouse Hippocampus And Retina, D. E. Philpott, W. Sapp, J. Miquel, K. Kato, R. Corbett, J. Stevenson, S. Black, K. A. Lindseth, E. V. Benton
Scanning Electron Microscopy
Eight month old C57BL6 mice were exposed (head only) to 0.5 rad or 50 rads of Argon particles at the Lawrence Berkeley Radiation Facility, CA. Neuromotor performance was assessed monthly for six months beginning twelve weeks post-irradiation using a ''string test". The decline in motor performance was dose-related and none of the animals was able to complete the task after four months of testing. Morphological changes were monitored six and twelve months post-irradiation by light and electron microscopy. The synaptic density in the CA-1 area of the hippocampus decreased six and twelve months after irradiation. The decrease after twelve months …