Life Sciences Commons^™

Voluntary Exercise Reduces Alzheimer’S-Like Pathology After Inflammation In Mice, Marielle K. Weintraub, Jordon D. White, Stephanie M. Turner, Samantha L. Hodges, Amanda Leigh Morin, Lindsey N. Sadler, Gary W. Boehm, Michael J. Chumley

International Journal of Exercise Science: Conference Proceedings

Current global statistics estimate that 44.4 million people are afflicted with dementia, and that 50%-75% of these patients suffer from Alzheimer’s disease (AD; Prince et al. 2013). AD, a progressive disorder categorized by neuronal and behavioral deterioration, is the 6^th leading cause of death in America (Alz facts and figure 2012). One hallmark pathology of AD is the presence of amyloid-beta (Aβ) in the brain, which can limit cell-to-cell communication, leading to cognitive deficits, and neuronal cell death. Although the exact origins of this disease still remain unknown, one possible catalyst of AD pathology is inflammation. Our lab has …