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Effect Of Holothurin On Sarcoma 180 And B-16 Melanoma Tumors In Mice, S.D. Cairns, C.A. Olmstead

Gulf and Caribbean Research

Holothurin, a biotoxic principle from the Cuvierian glands of the Bahamian sea-cucumber, Actinopyga agassizi, was studied as an anti-tumor agent capable of retarding tumor growth and prolonging the life of tumor-bearing mice. White Swiss mice injected with Sarcoma 180 had a mean survival time of 18.1 days with an average weight gain representing tumor and ascites fluid accumulation amounting to 25.1 grams in 15 days. Of five white Swiss mice with Sarcoma 180 receiving 0.15 mg Holothurin every other day, one was alive at 57 days and the average weight gain of the group was 10.4 grams in 15 …