Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
Investigating The Roles Of Rna Binding Protein Combinations In Neuronal Function And Organismal Behavior, Alexa Vandenburg
Investigating The Roles Of Rna Binding Protein Combinations In Neuronal Function And Organismal Behavior, Alexa Vandenburg
SMU Journal of Undergraduate Research
The Norris lab recently identified two RNA binding proteins required for proper neuron-specific splicing. The lab conducted touch- response behavioral assays to assess the function of these proteins in touch-sensing neurons. After isolating C. elegans worms with specific phenotypes, the lab used automated computer tracking and video analysis to record the worms’ behavior. The behavior of mutant worms differed from that of wild-type worms.
The Norris lab also discovered two possible RNA binding protein sites in SAD-1, a neuronal gene implicated in the neuronal development of C. elegans1. These two binding sites may control the splicing of SAD-1. The lab …
Combinatorial Genetics Of Rna Binding Proteins For Lifespan Regulation In C. Elegans, Nikita Tapiawala
Combinatorial Genetics Of Rna Binding Proteins For Lifespan Regulation In C. Elegans, Nikita Tapiawala
SMU Journal of Undergraduate Research
RNA binding proteins control post-transcriptional aspects of gene regulation. While transcriptional control over the aging process has been well-established, less is known about post-transcriptional control over the aging process. We have used CRISPR/Cas9 genetics to study combinations of RNA binding proteins in C. elegan, a transparent nematode or roundworm one millimeter in length, and their role in aging. The manner in which the research was conducted was through experimental laboratory work in which the lifespan of the nematodes was monitored until their death. The three mutations affecting RNA binding proteins that assays were performed with are exc-7, fox-1, and mbl-1. …
Investigating Peroxiredoxins Impact On Amps, Noah Earland
Investigating Peroxiredoxins Impact On Amps, Noah Earland
SMU Journal of Undergraduate Research
The Orr-Radyuk lab is interested in understanding the link between aging and genetic influences controlling the cell’s redox state, as determined by enzymes involved in reducing and oxidizing (redox) reactions. They have observed that Drosophila normally exhibit a shift towards a pro-oxidizing cellular environment and spikes in AMP levels, independent of infections, when they reach old age. Additionally, peroxiredoxins (PRXs), a family of thiol-dependent peroxidases, have been shown to impact lifespan, and regulate the same pro-oxidizing shift seen in advanced age. Beyond their peroxidase functions, RXRs can also interact with signaling pathways related to immunity. Previous data showed that PRXs …