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Developmental Reproductive Effects Of Exposure To Pharmaceutical Steroids In The Aquatic Environment: Studies On Mosquitofish (Gambusia Affinis Affinis),Roach (Rutilus Rutilus) And Medaka(Oryzias Latipes), Taisen Iguchi, Yoshinao Katsu, Hiroshi Urushitani, Anke Lange, Charles R. Tyler
Developmental Reproductive Effects Of Exposure To Pharmaceutical Steroids In The Aquatic Environment: Studies On Mosquitofish (Gambusia Affinis Affinis),Roach (Rutilus Rutilus) And Medaka(Oryzias Latipes), Taisen Iguchi, Yoshinao Katsu, Hiroshi Urushitani, Anke Lange, Charles R. Tyler
Journal of Marine Science and Technology
Pharmaceutical androgens and estrogens discharged into the aquatic environment are now known to induce adverse effects in fish and are a health concern for wildlife. Mosquitofish (Gambusia affinis) exposed to a pharmaceutical androgen, trenbolone, used to enhance cattle growth and found to pollute waters below feedlots in the USA, has been shown to alter the development of the anal fin of the females and disrupt gonopodium development in fry. In our work, we showed that altered gonopodium development was associated with disruption in the normal patterns of expression of 2 cloned androgen receptors. Furthermore, exposure to trenbolone at 1 µg/L …