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Full-Text Articles in Life Sciences
Role Of Histone Modifications In Meiosis, Mason Allen, Neeraj Joshi
Role Of Histone Modifications In Meiosis, Mason Allen, Neeraj Joshi
Undergraduate Research Posters 2012
Meiosis I is characterized by events taking place between homologous chromosomes called crossing over in which double stand breaks (DSB) are formed and repaired using the homologous chromosome as a template. To see if Gene A shared the same role as Gene B, double mutants were created to test chromosome segregation and DSB repair as compared with Gene B deletions. The spore viability of double mutants and their potential implications will be discussed.
Yeast 2-Hybrid Screen For T. Brucei Tin2- And Rap1- Intracting Proteins, Miao Wang, Fan Wu
Yeast 2-Hybrid Screen For T. Brucei Tin2- And Rap1- Intracting Proteins, Miao Wang, Fan Wu
Undergraduate Research Posters 2012
Telomeres are DNA-protein complexes located at the ends of linear chromosomes. Acting like a cap, they protect chromosome ends from degradation and rearrangement, maintaining genomic stability. Our lab has identified several T. brucei telomere proteins, including TRF (TTAGGG Repeat-binding Factor), TIN2 (TRF1-interacting Nulcear Protein 2) and RAP1 (Repressor Activator Protein 1) homologs. We are currently verifying the interactions between the new candidates and TbTIN2 or TbRAP1.
Structure-Function Of U11 Snrna In The Minor Splicing Pathway, Mark P. Biro, Jagjit Singh
Structure-Function Of U11 Snrna In The Minor Splicing Pathway, Mark P. Biro, Jagjit Singh
Undergraduate Research Posters 2012
In human, the majority of protein coding genes are interrupted by dispensable intervening sequences (introns). These introns are removed by nuclear precursor (pre) mRNA splicing process to produce a mature mRNA needed for productive protein production in the cell. We are studying the splicing of minor class or U12-type introns which are spliced by U11, U12, U4atac, U5 and U6atac snRNAs. U11 snRNA binds to the 5’ end or splice site of the intron by RNA-RNA base-pairing to initiate the splicing process. Our results show the functionality of the genetic mutation suppressor assay in establishing the role of U11 snRNA …