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Exploring New Chemotherapeutic Strategies Against Brain Cancer, Seol Kim, Anthony J. Berdis
Exploring New Chemotherapeutic Strategies Against Brain Cancer, Seol Kim, Anthony J. Berdis
Undergraduate Research Posters 2013
Approximately 4,000 children in the United States are diagnosed each year with a brain tumor. Brain cancers are the deadliest of all pediatric cancers as they have survival rates of less than 20%. Typical treatments include surgery and radiation therapy. However, chemotherapy is the primary therapeutic option for children, especially against aggressive brain tumors. An important chemotherapeutic agent is temozolomide, an alkylating agent that causes cell death by damaging DNA. In this project, we tested the ability of non-natural nucleosides developed in our lab in order to increase the ability of temozolomide to kill brain cancer cells. Our results show …