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Systems Biology Approaches For The Analysis Of High-Throughput Biological Data, Michele Donato

Wayne State University Dissertations

The identification of biological processes involved with a certain phenotype, such as a disease or drug treatment, is the goal of the majority of life sciences experiments.

Pathway analysis methods are used to interpret high-throughput biological data to identify such processes by incorporating information on biological systems to translate data into biological knowledge.

Although widely used, current methods share a number of limitations.

First, they do not take into account the individual contribution of each gene to the phenotype in analysis.

Second, most of the methods include parameters of difficult interpretation, often arbitrarily set.

Third, the results of all methods …