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A Comparative Study Of Larval Gene Expression Between A Paedomorphic And Metamorphic Species Of Ambystomatid Salamander, Meredith A. Boley

University of Kentucky Master's Theses

Ambystoma tigrinum undergoes an obligatory metamorphosis while A. mexicanum fails to metamorphose and exhibits paedomorphosis. While it is clear that salamander paedomorphosis is associated with genetic changes that delay developmental timing, it is not clear when and how these changes manifest during development. It is possible that paedomorphic and metamorphic larvae show equivalent patterns of developmental until late in the larval period, when brain regions become competent to stimulate the release of metamorphic hormones. To test this hypothesis, I compared gene expression patterns between the brains of A. mexicanum and A. t. tigrinum larvae. In support of the developmental equivalence …