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Full-Text Articles in Life Sciences
Mapping Auditory And Vestibular Response Neurons In The Optic Tectum Of Larval Zebrafish, Erika Marks, Arminda Suli
Mapping Auditory And Vestibular Response Neurons In The Optic Tectum Of Larval Zebrafish, Erika Marks, Arminda Suli
Undergraduate Honors Theses
Cellular mapping of the sensory receptive fields of brain structures is a critical step in understanding function and dysfunction in development. Deficits in the ability to receive, process and integrate the senses leads to difficulties recognizing and responding appropriately to stimuli. To understand how the senses are integrated, it is first necessary to map the neurons receptive to inputs from individual senses. The optic tectum of zebrafish is a structure known for its homology to the superior colliculus of mammals and is a center of multisensory integration – including visual, auditory, and somatosensory stimuli. However, the microcircuitry of this important …
Identifying And Knocking Out Non-Visual Opsins In The Optic Tectum Of Zebrafish Larvae, Sarah Jarrett
Identifying And Knocking Out Non-Visual Opsins In The Optic Tectum Of Zebrafish Larvae, Sarah Jarrett
Undergraduate Honors Theses
Deep brain photoreceptors (DBPs) are non-visual photoreceptors found in the brains of non-mammalian vertebrates like zebrafish. While using optogenetic techniques in our lab to photo-activate the ear (by expressing the light-gated channel: channelrhodopsin) in efforts of identifying optic tectum (OT) neurons that respond to and integrate auditory and visual stimuli, we found that violet light was able to elicit OT neuronal activity. OT activity was also detected in cases when visual and auditory stimulation was not possible due to removal of the eyes and absence of the exogenously expressed channelrhodopsin, respectively. Analyzing OT single-cell sequencing data of 7day post fertilization …
Identifying The 5’End Of The Camta1 Genes In Zebrafish, Morgan Fronk
Identifying The 5’End Of The Camta1 Genes In Zebrafish, Morgan Fronk
Undergraduate Honors Theses
Congenital heart diseases (CHDs) are a significant cause of infant death and are frequently caused by mutations in transcription factors. Camta1 (calmodulin binding transcription activator 1) is a transcription factor that has been proposed as a modulator in embryonic heart development and a possible cause of CHDs. The only other known member of its family in vertebrates is involved in activating a hypertrophy gene program in adult heart failure. Unlike camta2, camta1 is expressed in the embryonic heart during heart looping. However, few studies have been done on camta1. In zebrafish, there are two camta1 ohnologs (homologs created through …