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Articles 1 - 9 of 9
Full-Text Articles in Life Sciences
Regulation Of Dkk1, An Inhibitor Of The Wnt Signaling Pathway, By Dax-1 In Mouse Embryonic Stem Cells, Victor D. Gavallos
Regulation Of Dkk1, An Inhibitor Of The Wnt Signaling Pathway, By Dax-1 In Mouse Embryonic Stem Cells, Victor D. Gavallos
Undergraduate Honors Theses
DAX-1 is known to play a key role in the maintenance of pluripotency in mouse embryonic stem cells (mESC), such that elimination of DAX-1 (through methods such as RNAi) leads to the differentiation of ESC (Khalfallah et al. 2009). Earlier research by the Tzagarakis-Foster lab identified target genes of DAX-1 in mESC through PCR array methodology (Torres 2013). The Dickkopf 1 gene (Dkk1) was identified as a potential target of DAX-1 by these studies and has since been confirmed to be a DAX-1 target in mESC. However, to date very little is understood of the mechanism of DAX-1 repression of …
Relationship Between Relative Hive Entrance Position And Dance Floor Location, Chelsea E. Corrigan
Relationship Between Relative Hive Entrance Position And Dance Floor Location, Chelsea E. Corrigan
Undergraduate Honors Theses
It has been observed that returning honey bee foragers congregate with unemployed foragers and food receiver bees in a localized region of the hive known as the dance floor. Here, the returning foragers advertise food sources via the waggle dance. It was hypothesized that the close proximity of the dance floor to the hive entrance was related to foragers minimizing time and travel inside the hive. The hive entrance is conventionally located at the bottom of the hive. It was suggested that this location was ideal for easy removal of debris. This correlation between dance floor location and hive entrance …
Redesign Of Trans-Splicing Molecules For The Correction Of Dystrophia Myotonica Type 1 Toxic Rna Transcripts, Eleanor G. Harrison
Redesign Of Trans-Splicing Molecules For The Correction Of Dystrophia Myotonica Type 1 Toxic Rna Transcripts, Eleanor G. Harrison
Undergraduate Honors Theses
Dystrophia myotonica (DM1), one of the most common forms of muscular dystrophy, is caused by a repeated trinucleotide expansion in the DMPK gene. This mutation results in the accumulation of toxic cellular RNA transcripts. Spliceosome-mediated RNA trans-splicing (SMaRT) technology is a form of gene therapy that possesses the potential to correct these toxic RNA transcripts and thus cure the disease. Despite its promise, prior research applications of SMaRT technology to DM1 have been hampered by poor efficiency and have not been validated in a relevant model of the disease. In order to improve the efficiency of trans-splicing, this study examined …
The Integration Of Google Maps Into American Kestrel, Falco Sparvarius, Nest Trail Programs, Dylan M. Harper
The Integration Of Google Maps Into American Kestrel, Falco Sparvarius, Nest Trail Programs, Dylan M. Harper
Undergraduate Honors Theses
American Kestrel Nest Box Programs have been established since the mid 1960’s. The population of American Kestrels (Falco sparverius) along nest box trails has decreased by 47 percent since their original implementation. There are existing technologies that can help in the location of prime kestrel habitat (open fields with conspicuous perching locations) along highways, which reduces the amount of labor in searching for new box locations. These technologies can also help increase the efficiency of monitoring and maintaining kestrel nest trail programs. This study provides an example of how Google Maps can be implemented into a kestrel trail …
Neuromodulation Therapy Mitigates Heart Failure Induced Hippocampal Damage, Timothy P. Diperi
Neuromodulation Therapy Mitigates Heart Failure Induced Hippocampal Damage, Timothy P. Diperi
Undergraduate Honors Theses
Cardiovascular disease (CVD) is the leading cause of death in the United States. Nearly half of the people diagnosed with heart failure (HF) die within 5 years of diagnosis. Brain abnormalities secondary to CVD have been observed in many discrete regions, including the hippocampus. Nearly 25% of patients with CVD also have major depressive disorder (MDD), and hippocampal dysfunction is a characteristic of both diseases. In this study, the hippocampus and an area of the hippocampal formation, the dentate gyrus (DG), were studied in a canine model of HF. Using this canine HF model previously, we have determined that myocardial …
Expression Of Human Neutrophil Cathepsin G In Pichia Pastoris, Evan T. Perry
Expression Of Human Neutrophil Cathepsin G In Pichia Pastoris, Evan T. Perry
Undergraduate Honors Theses
Cathepsin G (CatG), a serine protease found in the azurophil granules of neutrophils, participates in killing engulfed microorganisms. CatG is a poorly understood enzyme, in part because it can only be obtained as mature enzyme purified from human blood, and because it seems to have dual specificity for chymotrypsin-like and trypsin-like substrates. Therefore, yeast Pichia pastoris was used to express immature recombinant human CatG to provide a source of the enzyme free of biohazards and to allow study of its dual specificity and C-terminal processing. To avoid potential cleavage by a yeast kexin protease, the amino sequence was modified without …
Eggshell Calcium Regulates Calcium Transport Protein Expression In An Oviparous Snake, Hannah Frye
Eggshell Calcium Regulates Calcium Transport Protein Expression In An Oviparous Snake, Hannah Frye
Undergraduate Honors Theses
One hypothesis explaining the numerous independent evolutionary transitions from oviparity to viviparity among squamates (snakes and lizards) proposed that squamate embryonic development is independent of eggshell calcium. Recent research showed at least 25% of the calcium in hatchling oviparous squamates is extracted from the shell. Though not a direct test, these results are inconsistent with the hypothesis. To directly test the hypothesis, we removed eggshell calcium (through peeling) early in development of Pantherophis guttatus (corn snake) eggs. Survivorship to hatching did not differ between peeled and intact eggs. Yet hatchlings from peeled eggs were shorter (273.6 ± 3.4 vs. 261.0 …
Polymorphic Membrane Protein Expression In Chlamydia/Hsv Co-Infected Cells, Julia S. Colgrove
Polymorphic Membrane Protein Expression In Chlamydia/Hsv Co-Infected Cells, Julia S. Colgrove
Undergraduate Honors Theses
The Chlamydiaceae are a bacterial family that contains a single genus: Chlamydia. The genus Chlamydia consists of 9 species that are obligate, intracellular pathogens. Untreated C. trachomatis infections can lead to serious health ramifications, such as ectopic pregnancy, tubal factor infertility, pelvic inflammatory disease, and long-term pelvic pain. In this study, it was found that a primary antibody dilution of 1:400 using methanol fixed HeLA cells, as derived from Carrasco, et al. protocol, was only optimal for PMP-C staining. Pmp-A, Pmp-B, and Pmp-F were found to stain brighter with formaldehyde fixed, infected HeLa cells and using different primary antibody dilutions. …
Where Do I Know That? A Distributed Multimodal Model Of Semantic Knowledge, Kevin M. Stubbs
Where Do I Know That? A Distributed Multimodal Model Of Semantic Knowledge, Kevin M. Stubbs
Undergraduate Honors Theses
As computers have grown more and more powerful, computational modeling has become an increasingly valuable tool for evaluating real world findings. Likewise, brain imaging has become increasingly powerful as is evidenced by recent fMRI findings which support the exciting possibility that semantic memory is segregated by modality in the brain (Goldberg et al., 2006b). The present study utilizes connectionist modeling to put the distributed multi-modal framework of semantic memory to the test, and represents the next step forward in the line of sensory-functional models. This model, based around the McRae et al. (2005) feature production norms, includes individual implementations of …