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Full-Text Articles in Life Sciences
Noncoding Rnas In Apoptosis: Identification And Function, Özge Tüncel, Merve Kara, Bi̇lge Yaylak, İpek Erdoğan, Bünyami̇n Akgül
Noncoding Rnas In Apoptosis: Identification And Function, Özge Tüncel, Merve Kara, Bi̇lge Yaylak, İpek Erdoğan, Bünyami̇n Akgül
Turkish Journal of Biology
Apoptosis is a vital cellular process that is critical for the maintenance of homeostasis in health and disease. The derailment of apoptotic mechanisms has severe consequences such as abnormal development, cancer, and neurodegenerative diseases. Thus, there exist complex regulatory mechanisms in eukaryotes to preserve the balance between cell growth and cell death. Initially, protein-coding genes were prioritized in the search for such regulatory macromolecules involved in the regulation of apoptosis. However, recent genome annotations and transcriptomics studies have uncovered a plethora of regulatory noncoding RNAs that have the ability to modulate not only apoptosis but also many other biochemical processes …
Identification Of Differentially Expressed Micrornas In Primary Esophageal Achalasia By Next-Generation Sequencing, Mahin Gholipour, Javad Mikaeli, Seyed Javad Mowla, Mohammad Reza Bakhtiarzadeh, Marie Saghaeian Jazi, Naeme Javid, Narges Fazlollahi, Masoud Khoshnia, Naser Behnampour, Abdolvahab Moradi
Identification Of Differentially Expressed Micrornas In Primary Esophageal Achalasia By Next-Generation Sequencing, Mahin Gholipour, Javad Mikaeli, Seyed Javad Mowla, Mohammad Reza Bakhtiarzadeh, Marie Saghaeian Jazi, Naeme Javid, Narges Fazlollahi, Masoud Khoshnia, Naser Behnampour, Abdolvahab Moradi
Turkish Journal of Biology
Molecular knowledge regarding the primary esophageal achalasia is essential for the early diagnosis and treatment of this neurodegenerative motility disorder. Therefore, there is a need to find the main microRNAs (miRNAs) contributing to the mechanisms of achalasia. This study was conducted to determine some patterns of deregulated miRNAs in achalasia. This case-control study was performed on 52 patients with achalasia and 50 nonachalasia controls. The miRNA expression profiling was conducted on the esophageal tissue samples using the next-generation sequencing (NGS). Differential expression of miRNAs was analyzed by the edgeR software. The selected dysregulated miRNAs were additionally confirmed using the quantitative …
Negative Regulation Of Diminutive Cancer Regulator Through Differentiation And Microrna Pathway Components In Drosophila Cells, Sumira Malik
Negative Regulation Of Diminutive Cancer Regulator Through Differentiation And Microrna Pathway Components In Drosophila Cells, Sumira Malik
Turkish Journal of Biology
Drosophila model is intensively studied for the development of cancer. The diminutive (dMyc), a homolog of the human MYC gene, is responsible for cell- apoptosis and its upregulation is responsible for determining the fate of cancerous growth in humans and Drosophila model. This work implores the requirement of dMyc and its expression as one of the major regulator of cancer with other proteins and repression of dMyc mRNA in Drosophila S2 cells. Here we report protein complex of Argonaute 1 (AGO1), Bag of marbles (Bam), and Brain tumor (Brat) proteins and not the individual factor of this complex repression of …
Single Nucleotide Polymorphisms In Micrornas Action As Biomarkers For Breast Cancer, Thanh Thi Ngoc Nguyen, Minh Thi Hong Tran, Vy Thi Lan Nguyen, Uyen Doan Phuong Nguyen, Giang Dien Thanh Nguyen, Luan Huu Huynh, Hue Thi Nguyen
Single Nucleotide Polymorphisms In Micrornas Action As Biomarkers For Breast Cancer, Thanh Thi Ngoc Nguyen, Minh Thi Hong Tran, Vy Thi Lan Nguyen, Uyen Doan Phuong Nguyen, Giang Dien Thanh Nguyen, Luan Huu Huynh, Hue Thi Nguyen
Turkish Journal of Biology
MicroRNAs (miRNAs) have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast cancer (BC). Ongoing investigations in malignant growth diagnostics have distinguished miRNAs as promising disease biomarkers. As with any other mRNAs, single nucleotide polymorphisms (SNPs) in DNA sequence encoding for miRNA (miR-SNPs) indeed lead to potential changes in the function of miRNA. In this study, miR-SNPs located in different miRNA sequence regions, which have been associated with BC in different ways, and …
Microrna Prediction Based On 3d Graphical Representation Of Rnasecondary Structures, Müşerref Duygu Saçar Demi̇rci̇
Microrna Prediction Based On 3d Graphical Representation Of Rnasecondary Structures, Müşerref Duygu Saçar Demi̇rci̇
Turkish Journal of Biology
MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression. While a miRNA can target hundreds of messenger RNA (mRNAs), an mRNA can be targeted by different miRNAs, not to mention that a single miRNA might have various binding sites in an mRNA sequence. Therefore, it is quite involved to investigate miRNAs experimentally. Thus, machine learning (ML) is frequently used to overcome such challenges. The key parts of a ML analysis largely depend on the quality of input data and the capacity of the features describing the data. Previously, more than 1000 features were suggested for miRNAs. Here, it is shown that …
Identification Of Conserved Mirna Molecules In Einkorn Wheat (Triticum Monococcum Subsp. Monococcum) By Using Small Rna Sequencing Analysis, Ercan Selçuk Ünlü, Sara Bataw, Di̇dem Şen, Yunus Şahi̇n, Nusret Zenci̇rci̇
Identification Of Conserved Mirna Molecules In Einkorn Wheat (Triticum Monococcum Subsp. Monococcum) By Using Small Rna Sequencing Analysis, Ercan Selçuk Ünlü, Sara Bataw, Di̇dem Şen, Yunus Şahi̇n, Nusret Zenci̇rci̇
Turkish Journal of Biology
Triticum monococcum subsp. monococcum as a first cultivated diploid wheat species possesses desirable agronomic and quality characteristics. Drought and salinity are the most dramatic environmental stress factors that have serious impact on yield and quality of crops; however, plants can use alternative defense mechanisms against these stresses. The posttranscriptional alteration of gene expression by microRNAs (miRNAs) is one of the most conserved mechanisms. In plant species including wheat genomes, miRNAs have been implicated in the management of salt and drought stress; however, studies on einkorn wheat (Triticum monococcum subsp. monococcum) are not yet available. In this study, we aimed to …
Analysis Of Global Micrornaome Profiles Of Caenorhabditis Elegans Oocytes And Early Embryos, Selen Güçlü Durgun, Ahmet Raşi̇t Öztürk, Arzu Atalay
Analysis Of Global Micrornaome Profiles Of Caenorhabditis Elegans Oocytes And Early Embryos, Selen Güçlü Durgun, Ahmet Raşi̇t Öztürk, Arzu Atalay
Turkish Journal of Biology
One of the most complex cell transformations in biology is the remodeling of a fertilized oocyte into a totipotent zygote. There is no transcription during this event, and therefore mRNAs and proteins accumulated in the oocyte during oogenesis are utilized until zygotic genome activation. In order to differentiate into somatic cells, the embryo must erase the totipotency signature coming from the oocyte cytoplasm in the somatic blastomeres. In this study, the microRNAome profiles of oocytes and early embryos before and after zygotic genome activation were identified. By using next-generation high-throughput pyrosequencing and miRNA microarray techniques, miRNAome profiles of Caenorhabditis elegans …