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Possible Mechanisms Behind Impaired Glucose Metabolism In Niacin-Deficient Mice, Sierra Lopez
Possible Mechanisms Behind Impaired Glucose Metabolism In Niacin-Deficient Mice, Sierra Lopez
Student Research Symposium
Niacin, a component of vitamin B3, is necessary for the synthesis of nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme in many biologic functions, including a number of metabolic processes that regulate glucose and fat homeostasis. Humans obtain niacin in its dietary form, common in meats, nuts, legumes and some leafy vegetables. While severe niacin deficiency, or pellagra, has been drastically reduced in the United States, some populations remain vulnerable to deficiency, particularly pregnant women, cancer patients, the elderly and alcoholics. Age-related NAD deficiency is emerging as being positively correlated with cognitive decline and impaired dermal repair.. At the …
Roles Of Nad+ In Testicular Aging And Epigenetic Sperm Modifications, Renata Hoskova
Roles Of Nad+ In Testicular Aging And Epigenetic Sperm Modifications, Renata Hoskova
Student Research Symposium
Since 1980, the average age of first-time fathers has been increasing. With increased age, sperm chromatin quality and nicotinamide adenine dinucleotide (NAD) levels are reduced. In order to condense around protamines, sperm DNA undergoes breaks, at which time epigenetic reprogramming occurs. In humans, about 2% of DNA stays wound to histones in spermatozoa. Histones carry post-translational modifications that control gene activity and have the potential to transmit epigenetic information to the offspring. Analysis of epigenetic sperm modifications is being conducted within niacin deficient versus niacin replete mice. The experimental plan includes the characterization of histone exchange in elongating spermatids via …