Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Identification Of The Role Of Swra In Copper Induced Poly-Gamma-Glutamic Acid Production In Bacillus Subtilis, Maya Addison
Identification Of The Role Of Swra In Copper Induced Poly-Gamma-Glutamic Acid Production In Bacillus Subtilis, Maya Addison
Scripps Senior Theses
Each year over 2.8 million Americans are infected by an antibiotic resistant strain of bacteria with over 35, 000 dying as a result (CDC). The lack of development of new antibiotics has renewed interest in the antimicrobial properties of copper. Gram positive bacterium such as Bacillus subtilis produce poly-gamma-glutamic acid (γ-PGA) to sequester excess copper ions. swrA has shown to be essential for proper activation of the pgs operon by phosphorylated DegU via an unknown mechanism. This study seeks to determine the role of swrA in copper induced gamma-PGA production and if swrA and ppsB are involved in copper resistance. …