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Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
Neuroscience Of Stress & Addiction: A Digitally Animated Video On How These Brain Systems Interact And Influence Each Other From Early Life Stress To Withdrawal, Claire Bacon-Brenes
Neuroscience Of Stress & Addiction: A Digitally Animated Video On How These Brain Systems Interact And Influence Each Other From Early Life Stress To Withdrawal, Claire Bacon-Brenes
Scripps Senior Theses
Alcohol addiction and stress are both highly prevalent health conditions impacting our society. With stress on the rise in college students and alcohol addiction impacting 19.7 million Americans as of 2017, communication around the science of these issues is ever important because of stigma around them. This digitally animated video effectively explains alcohol addiction and stress on a neurobiological level with college science students as the audience, including two important examples of how stress and alcohol addiction interact. Stress experienced early in life is a known risk factor in developing addiction due to dysregulation of the reward pathway and altered …
Intercropping For Water Conservation: Environmental And Economic Implications Of A Sustainable Farming Practice In California's Central Valley, Sophie Baker
Scripps Senior Theses
California’s agricultural sector is the biggest water consumer in the state and faces intense pressure to reduce its overall water usage. Industrialized monoculture systems dominate the industry and often disregard long-term environmental and economic externalities for short-term profit maximization. To maintain longstanding food security and economic stability as well as protect the state’s water supply, it is critical that these systems transition to more sustainable and resilient production mechanisms. As an alternative to monoculture, intercropping affords greater potential to conserve water, protect soil quality, and increase crop yields, among other metrics of sustainability. However, there has been much controversy over …
Complex Ciliary Flows Around Stentor Polymorphus In Solutions Of 2% Buttermilk And Chlamydomonas Reinhardtii, Eliana B. Smithstein
Complex Ciliary Flows Around Stentor Polymorphus In Solutions Of 2% Buttermilk And Chlamydomonas Reinhardtii, Eliana B. Smithstein
Scripps Senior Theses
Stentor are large, unicellular ciliates of the Heterotricha order. They live in both freshwater and marine habitats and are mostly found in ponds. I studied Stentor polymorphus, which is a species of Stentor only recently discovered to be lab culturable. They range from 0.5-1.5mm in length and are unusual because they live with endosymbiotic algae and are much more likely than other, more widely studied, species of Stentor to form aggregates while they are eating. There are three main components to this thesis: First, I established protocols for keeping a viable S. polymorphus culture, since no protocols had been …
Identification Of Imiquimod As A Potential Combination For Anti-Cd47 Antibodies In Cancer Therapy, Nicole Brittaney Pang
Identification Of Imiquimod As A Potential Combination For Anti-Cd47 Antibodies In Cancer Therapy, Nicole Brittaney Pang
Scripps Senior Theses
The avenues of targeted immunotherapy offers a promise of less toxic treatment options for those battling different forms of cancer. Specifically, the process of hijacking a patient’s own immune system to fight cancer from within versus using external treatments like chemotherapy which is extremely damaging to the patient. One such avenue includes the usage of monoclonal antibodies as an effective modality for immunotherapy. Cluster of Differentiation 47 (CD47), also known as the ‘don’t eat me signal’, aids in cell proliferation and evasion of phagocytosis and has been found to be a target for stopping tumorigenesis. Previous research has been successful …
Characterizing Changes In The Colonic Epithelium Of Lrig3 Null Mice, Natalie Pedicino
Characterizing Changes In The Colonic Epithelium Of Lrig3 Null Mice, Natalie Pedicino
Scripps Senior Theses
The lining of the colon, or colonic epithelium, is a very dynamic and highly regulated tissue in the human body. Colonic stem cells are a key component of this tissue, and they make up the stem cell niche, which is found at the base of the colonic crypt. Regeneration of the colonic epithelium, which occurs on a weekly basis, is a complex process, and proteins responsible for directing regeneration are still being discovered. Two critical regulatory proteins, Lrig1 and Lrig3, have been shown to modulate the EGFR pathway, a key signaling pathway for growth, differentiation, and regeneration. Data from the …