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Full-Text Articles in Life Sciences
Ultrastructural Features Of Osteoclasts In Situ, L. De Saint-Georges, S. C. Miller, B. M. Bowman., W. S. S. Jee
Ultrastructural Features Of Osteoclasts In Situ, L. De Saint-Georges, S. C. Miller, B. M. Bowman., W. S. S. Jee
Scanning Microscopy
The morphology of in situ osteoclasts on endocortical surfaces of the femoral midshaft was examined by scanning electron microscopy. Mice were perfusion fixed and bone marrow plugs were flushed out of femoral diaphyseal cylinders. The bones were split longitudinally and the endocortical surfaces examined. This method left on the bone surface most of the endosteal cells in their natural, in situ shape and position. Most of the bone surface was lined by contiguous bone lining cells covering resting bone surfaces, making a clear physical barrier between the bone and marrow compartments. On resorption surfaces, which were characterized by excavation cavities, …
Bone Lining Cells: Structure And Function, Scott C. Miller, Louis De Saint-Georges, Beth M. Bowman, Webster S. S. Jee
Bone Lining Cells: Structure And Function, Scott C. Miller, Louis De Saint-Georges, Beth M. Bowman, Webster S. S. Jee
Scanning Microscopy
Bone lining cells (BLC's) cover inactive (nonremodeling) bone surfaces, particularly evident in the adult skeleton. BLC's are thinly extended over bone surfaces, have flat or slightly ovoid nuclei, connect to other BLC's via gap junctions, and send cell processes into surface canaliculi. BLC's can be induced to proliferate and differentiate into osteogenic cells and may represent a source of "determined" osteogenic precursors. BLC's and other cells of the endosteal tissues may be an integral part of the marrow stromal system and have important functions in hematopoiesis, perhaps by controlling the inductive microenvironment. Because activation of bone remodeling occurs on inactive …