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Full-Text Articles in Life Sciences
Social Defeat Stress Induces Depression-Like Behavior And Alters Spine Morphology In The Hippocampus Of Adolescent Male C57bl/6 Mice, Sergio D. Iñiguez, Antonio Aubry, Lace M. Riggs, Jason B. Alipio, Roseanna M. Zanca, Francisco J. Flores-Ramirez, Mirella A. Hernandez, Steven J. Nieto, David Musheyev, Peter Serrano
Social Defeat Stress Induces Depression-Like Behavior And Alters Spine Morphology In The Hippocampus Of Adolescent Male C57bl/6 Mice, Sergio D. Iñiguez, Antonio Aubry, Lace M. Riggs, Jason B. Alipio, Roseanna M. Zanca, Francisco J. Flores-Ramirez, Mirella A. Hernandez, Steven J. Nieto, David Musheyev, Peter Serrano
Publications and Research
Social stress, including bullying during adolescence, is a risk factor for common psychopathologies such as depression. To investigate the neural mechanisms associated with juvenile social stress-induced mood-related endophenotypes, we examined the behavioral, morphological, and biochemical effects of the social defeat stress model of depression on hippocampal dendritic spines within the CA1 stratum radiatum. Adolescent (postnatal day 35) male C57BL/6 mice were subjected to defeat episodes for 10 consecutive days. Twenty-four h later, separate groups of mice were tested on the social interaction and tail suspension tests. Hippocampi were then dissected and Western blots were conducted to quantify protein levels for …