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Molecular Events In The Cell Types Of The Olfactory Epithelium During Adult Neurogenesis, Paula M. Heron, Arnold J. Stromberg, Patrick Breheny, Timothy S. Mcclintock
Molecular Events In The Cell Types Of The Olfactory Epithelium During Adult Neurogenesis, Paula M. Heron, Arnold J. Stromberg, Patrick Breheny, Timothy S. Mcclintock
Physiology Faculty Publications
BACKGROUND: Adult neurogenesis, fundamental for cellular homeostasis in the mammalian olfactory epithelium, requires major shifts in gene expression to produce mature olfactory sensory neurons (OSNs) from multipotent progenitor cells. To understand these dynamic events requires identifying not only the genes involved but also the cell types that express each gene. Only then can the interrelationships of the encoded proteins reveal the sequences of molecular events that control the plasticity of the adult olfactory epithelium.
RESULTS: Of 4,057 differentially abundant mRNAs at 5 days after lesion-induced OSN replacement in adult mice, 2,334 were decreased mRNAs expressed by mature OSNs. Of the …