Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Gβγ Dependent Modulation Of Cytoskeleton And Neurite Outgrowth Involves The Pi3k/Akt/Gsk-3Β Pathway, Jose L. Varela
Gβγ Dependent Modulation Of Cytoskeleton And Neurite Outgrowth Involves The Pi3k/Akt/Gsk-3Β Pathway, Jose L. Varela
Open Access Theses & Dissertations
Assembly and disassembly of microtubules is critical for axon and dendrite formation and neurite outgrowth. Previous studies have shown that βγ subunits of heterotrimeric G proteins promote microtubule (MT) assembly in vitro and in cultured PC12 cells. Recently, it was found that the interaction of Gβγ with MTs is important for nerve growth factor (NGF)-induced neuronal differentiation of PC12 cells and that the blocking of the interaction between Gβγ and tubulin/MT disrupted MTs, inhibited neurite outgrowth and induced axonal damage indicating the involvement of Gβγ in these processes. A different pathway involving the receptor tyrosine kinase (TrkA) and its downstream …