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Imperatorin A Furocoumarin Inhibits Periplasmic Cu-Zn Sod Of Shigella Dysenteriae Their By Modulates Its Resistance Towards Phagocytosis During Host Pathogen Interaction, Raja Sb, Murali Mr, Roopa K, Devaraj Sn
Imperatorin A Furocoumarin Inhibits Periplasmic Cu-Zn Sod Of Shigella Dysenteriae Their By Modulates Its Resistance Towards Phagocytosis During Host Pathogen Interaction, Raja Sb, Murali Mr, Roopa K, Devaraj Sn
Murali Malliga Raman
Shigella dysenteriae continues to be a major health problem, which leads to death, due to diarrhoea and dysentery, predominantly in children below the age of 5. Bacterial invasion of the colonic epithelium leads to severe inflammation together with bacterial dissemination generates abscesses and ulcerations. Periplasmic copper, zinc super oxide dismutase of Shigella protects it from exogenous superoxide produced by host, during its invasion. Hence, in present study an attempt was made to study the effect of aqueous extract of Aegle marmelos on host and pathogen defence. Histology analysis of rat ileal loop showed the loss of virulence in aqueous extract …
Lactobacilli Inhibit Shigella Dysenteriae 1 Induced Pro-Inflammatory Response And Cytotoxicity In Host Cells Via Impediment Of Shigella-Host Interactions, Murali Mr, Moorthy G, Niranjali Devaraj S
Lactobacilli Inhibit Shigella Dysenteriae 1 Induced Pro-Inflammatory Response And Cytotoxicity In Host Cells Via Impediment Of Shigella-Host Interactions, Murali Mr, Moorthy G, Niranjali Devaraj S
Murali Malliga Raman
OBJECTIVE: Shigella dysenteriae Type 1 dysentery is a major cause of morbidity and mortality in children from less developed and developing countries. The present study explores the hypothesis that lactobacilli protect the host cell during S. dysenteriae Type 1 infection and its mechanism of action. METHODS: Caco-2 cells incubated for 1h with Lactobacillus rhamnosus or Lactobacillus acidophilus at the multiplicity of infection of 100, either alone or in combination followed by addition of Shigella at the same multiplicity of infection for 5h served as treatment groups. Cells incubated with Shigella without lactobacilli addition served as infected cells. At the end …
Differential Expression Of Ompc And Ompf In Multidrug-Resistant Shigella Dysenteriae And Shigella Flexneri By Aqueous Extract Of Aegle Marmelos, Altering Its Susceptibility Toward Beta-Lactam Antibiotics, Raja Sb, Murali Mr, Devaraj Sn
Differential Expression Of Ompc And Ompf In Multidrug-Resistant Shigella Dysenteriae And Shigella Flexneri By Aqueous Extract Of Aegle Marmelos, Altering Its Susceptibility Toward Beta-Lactam Antibiotics, Raja Sb, Murali Mr, Devaraj Sn
Murali Malliga Raman
Steadily increasing resistance among Shigella to beta-lactams, aminoglycosides, and tetracycline has compromised the utility of these commonly used antimicrobial agents. Also, undesirable side effects of certain antibiotics have triggered immense interest in search of alternative therapies using medicinal plants. One such medicinal plant used since ancient times to cure diarrhea is Aegle marmelos. The present study exemplifies the susceptibility of beta-lactam-resistant Shigella dysenteriae and Shigella flexneri toward beta-lactam antibiotics, when grown in the presence of aqueous extract of A. marmelos (AEAM), by altering porin channels. This was demonstrated by antibiotic sensitivity test using disc diffusion method and MIC test. Susceptibility …