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3d-Printed Polycaprolactone-Chitosan Based Drug Delivery Implants For Personalized Administration, Yutong Yang, Haichao Wu, Qiliang Fu, Xinfeng Xie, Yongming Song, Min Xu, Jian Li
3d-Printed Polycaprolactone-Chitosan Based Drug Delivery Implants For Personalized Administration, Yutong Yang, Haichao Wu, Qiliang Fu, Xinfeng Xie, Yongming Song, Min Xu, Jian Li
Michigan Tech Publications
Fused deposition molding (FDM) can complete most complex preparation of drug delivery implants to meet the personalized needs of patients. However, the drug activity has strict requirements on processing temperature and preparation method of filaments, the implant also has strict biocompatibility requirements for the materials. In this study, a drug delivery implant was prepared with good biocompatibility, controlled and efficient drug release using FDM printing for personalized administration. Drug-loaded filaments were developed for FDM process by hot-melt extrusion (HME). Polycaprolactone was used as a drug delivery carrier, and ibuprofen as the model drug. Notably, chitosan was dissolved to form controlled …