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A Test Of The Hypothesis That Environmental Chemicals Interfere With Thyroid Hormone Action In Human Placenta, Katherine Geromini
A Test Of The Hypothesis That Environmental Chemicals Interfere With Thyroid Hormone Action In Human Placenta, Katherine Geromini
Masters Theses 1911 - February 2014
Thyroid hormone is essential for normal brain development and recognition of this has led to universal screening of newborns for thyroid function to ensure that circulating levels of thyroid hormone are within a range known to be supportive of normal growth and mental development. Environmental chemicals that interfere with thyroid function are known to inhibit normal growth and mental development. Work from our lab and from labs internationally demonstrates in animal systems that some industrial chemicals such as PCBs, PBDEs, and others may interact with the thyroid hormone receptor(s) in ways that are not predicted by changes in serum thyroid …