Life Sciences Commons^™

Evaluation Of Α-Pyrrolidindovalerophenone (Α-Pvp) And Its Isomers In Male And Female Sprague-Dawley Rats Trained To Discriminate Mdpv, Kaley Cargile

Masters Theses

Recreational use of synthetic cathinones, 3,4-methylenedioxypyrovalerone (MDPV) and α‐pyrrolidinovalerophenone (α‐PVP), has become increasingly popular, thus prompting characterization of their behavioral and neurochemical effects. MDPV has been studied for several years now, though there is still much unknown about α‐PVP, and its isomers. The primary objective of this study was to characterize the discriminative effects of α‐PVP and its isomers in comparison to MDPV. Male and female Sprague-Dawley rats were trained to discriminate 0.5mg/kg MDPV from saline injections under a fixed ratio 20 (FR 20) schedule of food reinforcement. Substitution tests were conducted with MDPV (0.05-0.5mg/kg), α‐PVP (0.05-0.5mg/kg), (S)-α‐PVP (0.05-1mg/kg) and …

Identification And Characterization Of Possible Multiple Binding Sites For ((3)H)8-Oh-Dpat In The Hippocampus, Dawna Lea Evans

Masters Theses

No abstract provided.

Fixed-Ratio Size As A Determinant Of The Development Of Tolerance To Morphine, Mark J. Nickel

Masters Theses

The acute and chronic effects of morphine were examined in pigeons exposed to a multiple schedule with fixed ratio 5, 25, and 125 components. Acute exposure to morphine (0.56-10.0 mg/kg) resulted in rate reductions under each component when the dose was 1 mg/kg or higher. With chronic exposure to 5.6 mg/kg, tolerance to the rate-reducing effects of morphine was evident under each fixed ratio component. The development of tolerance was determined to some extent by fixed-ratio size, a result similar to earlier findings with cocaine.

Cocaine And Timing: Drug Effects Under A Mixed Fixed-Interval Extinction Schedule, Vincent O. Hodge

Masters Theses

The effects of cocaine hydrochloride (3.2-56.2 mg/kg) were determined in rats performing under a mixed fixed-interval 60-seconds extinction 120-seconds schedule of food delivery. Responses were recorded in successive 5-second bins. With the exception of the highest dose (56.2 mg/kg), cocaine did not significantly affect rate of responding under the fixed-interval component or extinction component, or the time of peak responding under the extinction component. The highest dose significantly reduced response rates and shifted the time of peak responding leftward to quicker and earlier moments. Results are discussed in terms of possible rate- and time-dependent effects of stimulant drugs.

1-Nitronaphthalene Causes Ultrastructural Changes Primarily In Nonciliated Bronchiolar Epithelium Followed By Ciliated Epithelium In The Rat, John-Michael Sauer

Masters Theses

This study describes morphological changes in the lung at several time intervals following a single injection of 1-Nitronaphthalene (100 mg/kg intraperitoneal) in male Sprague-Dawley rats using transmission and scanning electron microscopy. Dilation of the smooth endoplasmic reticulum and mitochondrial distension in the nonciliated bronchiolar (Clara) cells was apparent as early as 1 hour after injection, while adjacent ciliated cell showed minimal changes. At 6 hours, when respiratory distress was apparent in the animals, Clara and ciliated cells exhibited chromatin clumping, loss of mitochondrial cristae and cytoplasmic vacuolization. Also at 6 hours, the interstitial area around the terminal bronchioles was infiltrated …

Effects Of Phenobarbital In Combination With Phenytoin Or Valproic Acid On The Delayed-Matching-To-Sample Performance Of Pigeons, Catherine Ann Karas

Masters Theses

The present study examined the effects of phenobarbital (S, 10,20, and 40 mg/kg), phenytoin (2.5, 5, 7.5, and 15 mg/kg), and valproic acid (40, 60, 80, and 120 mg/kg), and those of phenobarbital (10 and 20 mg/kg) in combination with phenytoin (2.5,5, and 7.5 mg/kg) or valproic acid (40, 60, and 80 mg/kg), on the delayed-matching-to-sample performance of pigeons. In general, high doses of each individual drug reduced accuracy. Drug combinations also reduced accuracy relative to control values. Reductions in accuracy produced by drug combinations were very similar in magnitude to those predicted by a response-addition model of drug interaction.

Pathophysiology Of Hemorrhagic Shock And The Protective Effects Of Antioxidants, Annette Elizabeth Fleckenstein

Masters Theses

Considerable attention has focused on the role of free radicals in the pathophysiology of hemorrhagic shock. In this study, four pharmacological mechanisms for antagonizing free radical generation or reactions were compared in terms of their efficacy in attenuating post-hemorrhage (post-reinfusion) cardiovascular collapse. These included blocking arachidonic acid oxidation by cyclooxygenase (eg; ibuprofen), inhibiting superoxide radical production by xanthine oxidase (eg; oxypurinol), chelating iron (eg; desferal), and inhibiting lipid peroxidation (eg; U74006F and U78517G, Upjohn Company, Kalamazoo, Michigan).

Cardiovascular function, cerebral blood flow, arterial blood gases, serum glucose, and plasma vitamin E were examined in a hemorrhage/reperfusion model using urethane-anesthetized rats. …

Reaction Of 2,2,6-Trimethyl-1,3-Dioxin-4-One With Isocyanate Derivatives And The Synthesis Of 2,3,4,6-Tetra-O-Acetyl-Dglucopyranosyl Phenyl Carbodiimide, Tung Van Le

Masters Theses

This research was undertaken to study the synthesis and reactions of isocyanates with diketenes, the synthesis of glycosyl carbodiimide.

The 1,3-oxazine-2,4-dione compounds could be useful in the medicinal chemistry field and the agricultural field, the research using glycosyl carbodiimide as a synthon shows great promise for the medicinal chemistry field.

Acute Effects Of Phenytoin And Thioridazine, Alone And Combination, Upon Water Intake And Body Weight Changes In Rats, Miriana Witzig-Krstic

Masters Theses

Concommitant medication of anticonvulsants and psychotropics appears to be predominant among mentally retarded, geriatric, and psychiatric in- and out-patient populations. Despite suggested interaction and toxicity resulting from such combination treatment, substantial data remains unavailable. This study was designed to explore effects of dual treatment of thioridazine

Analogues Of Steffimycinone, David Wayne Elrod

Masters Theses

Several analogues of Steffimycinone - an anthracycline antitumor antibiotic - have been prepared. Modifications were made at C-7 and C-10 of the non-aromatic A ring portion of the anthracycline nucleus. Compounds with nitrogen substituents were prepared. The synthesis of these compounds is discussed as well as their antitumor activity. The unsuccessful approaches to several other analogues are also discussed.

Fetal Alcohol Effects: A Review Of The Current Literature And A Proposed Study Of The Possible Additive Effects Of Marihuana And Alcohol On The Fetus, Shirley Lange Kamp

Masters Theses

The purpose of this paper was to review the current state of knowledge regarding the effects of alcohol ingestion during pregnancy, to determine the specific issues that remain under speculation, and to develop a theoretical research design which might aid in determining the role, if any, of marihuana in compounding fetal alcohol effects.

The literature reviewed indicated that alcohol creates a continuum of fetal effects from mild abnormalities to the full fetal alcohol syndrome; current marihuana studies suggest possible adverse effects on the fetus. The research model was based on this evidence, the well documented usage of both drugs by …

Antibiotic Potential In The Liverworts, Especially Ricciocarpus Natans (L.) And Marchantia Polymorpha (L.), Theodore Roy Shields

Masters Theses

No abstract provided.

Production Of Acute Duodenal Ulcers In Rats By Infusion Of Gastric Secretogogues, Thomas John Stout

Masters Theses