Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Biology (5)
- Medicine and Health Sciences (3)
- Genetics (2)
- Genetics and Genomics (2)
- Medical Specialties (2)
-
- Microbiology (2)
- Oncology (2)
- Pharmacology (2)
- Pharmacology, Toxicology and Environmental Health (2)
- Biotechnology (1)
- Cell Biology (1)
- Cell and Developmental Biology (1)
- Ecology and Evolutionary Biology (1)
- Mathematics (1)
- Neuroscience and Neurobiology (1)
- Physical Sciences and Mathematics (1)
- Psychiatry and Psychology (1)
- Statistics and Probability (1)
- Virology (1)
- Keyword
-
- CLEFMA (2)
- Cancer (2)
- Cisplatin (2)
- EF-24 (2)
- 3-D Shape Perception (1)
-
- Ambystoma opacum (1)
- Antibiotic Resistant Bacteria (1)
- Antimicrobial Resistance Genes (1)
- Antitermination (1)
- Bacteriophage (1)
- Cell Culture (1)
- Cell Migration (1)
- Cross-Modal (1)
- Differential Equations (1)
- E. coli (1)
- Enteric Bacteria (1)
- Fecal Coliforms (1)
- Gene Expression (1)
- Haptics (1)
- Isolation-by-distance (1)
- Isolation-by-resistance (1)
- Landscape Genetics (1)
- Livestock (1)
- Mammoth Cave (1)
- Marbled Salamander (1)
- Markov Chain Monte Carlo (1)
- Mathematical Modeling (1)
- Metropolis-Hastings (1)
- Parallel Tempering (1)
- Promoter (1)
Articles 1 - 7 of 7
Full-Text Articles in Life Sciences
Natural And Artificial Object Recognition: The Superiority Of Natural Shape Features, Lauren Pedersen
Natural And Artificial Object Recognition: The Superiority Of Natural Shape Features, Lauren Pedersen
Mahurin Honors College Capstone Experience/Thesis Projects
The purpose of this study was to evaluate the ability of 44 young adults (mean age = 21.7 years) to compare natural and artificial three-dimensional (3-D) objects using their senses of vision and touch. Previous research has indicated that the information content provided by a stimulus set can have a significant effect on a participant’s ability to perform cross-modal object recognition tasks. A primary goal of the present study was to understand what shape features are transferable between visual and haptic modalities. Participants haptically manipulated objects from one of two stimulus sets: bell peppers (Capsicum annuum) and sinusoidally-modulated spheres (SIMS). …
Using Computational Bayesian Statistics To Analyze Parameters In A Differential Equation Model, Jacob Menix
Using Computational Bayesian Statistics To Analyze Parameters In A Differential Equation Model, Jacob Menix
Mahurin Honors College Capstone Experience/Thesis Projects
The purpose of this project is to use Bayesian statistics to analyze values of parameters for a previously developed system of differential equations which describes the healing process of diabetic foot ulcers. The model describes the relationships between matrix metalloproteinases (MMPs), their inhibitors (TIMPs), and extracellular matrix (ECM). A Bayesian approach is used when the availability of data is sparse, as it is in this case. Delayed Rejection Adaptive Metropolis (DRAM), a MATLAB implementation of a Metropolis-Hastings algorithm, is used to estimate parameters. This approach with the individual patient data allows us to estimate and compare parameters and their pairwise …
Antibiotic Resistance Of Bacteria Isolated From Soils, Jessica Vaughan
Antibiotic Resistance Of Bacteria Isolated From Soils, Jessica Vaughan
Mahurin Honors College Capstone Experience/Thesis Projects
After the discovery of antibiotics, antibiotics have been increasingly implemented into human and veterinary medicine. In addition, antibiotics are inserted into animal feed for non-therapeutic purposes, which potentially leads to the development of antibiotic-resistant pathogens. When the livestock excrete waste onto the soil, the antibiotic resistant bacteria are introduced to the environment. With soil collected from different farms throughout the Bowling Green area, the microbial communities were analyzed to determine its bacterial compositions and their resistances to common antibiotics through a modified agar dilution technique. Once resistant colonies were isolated, they underwent more testing to determine if the colonies could …
Landscape Genetics Of Ambystoma Opacum In Mammoth Cave National Park, Haley Austin
Landscape Genetics Of Ambystoma Opacum In Mammoth Cave National Park, Haley Austin
Mahurin Honors College Capstone Experience/Thesis Projects
No abstract provided.
Investigating The Synergistic Effects Of Two Curcuminoids And Cisplatin On Cancer Cell Migration, Blaine Patty
Investigating The Synergistic Effects Of Two Curcuminoids And Cisplatin On Cancer Cell Migration, Blaine Patty
Mahurin Honors College Capstone Experience/Thesis Projects
Cisplatin is a common chemotherapy drug used to treat various cancers; however, it is relatively ineffective against many cancers, including several types of lung cancer. One approach that could improve cisplatin’s effect is to combine it with another drug that produces a synergistic response greater than either drug alone. Curcumin, a naturally occurring plant compound, has been investigated for synergisms in conjunction with cisplatin chemotherapy, but curcumin use is hampered by its low bioavailability. This project investigated whether two synthetic curcumin analogs, EF-24 and CLEFMA (curcuminoids), which have greater solubility than curcumin, could, when combined with cisplatin, decrease the migration …
Investigating The Synergistic Effects Of Two Curcuminoids And Cisplatin On Cancer Cell Reactive Oxygen Species, Matthew Millay
Investigating The Synergistic Effects Of Two Curcuminoids And Cisplatin On Cancer Cell Reactive Oxygen Species, Matthew Millay
Mahurin Honors College Capstone Experience/Thesis Projects
Cisplatin is an anticancer drug which can cause the production of reactive oxygen species (ROS) that kill cancer cells. Curcumin is a naturally occurring plant compound that can increase ROS levels in cancer cells and enhance the activity of cisplatin against cancer, but it exhibits poor bioavailability. We investigated whether two synthetic curcumin analogs (curcuminoids), EF-24 and CLEFMA, with anti-cancer activity and improved bioavailability, increased cisplatin’s effect against cancer. A spectrophotometric fluorescent ROS assay was used to determine if cisplatin, the curcuminoids or combinations of cisplatin with a curcuminoid affected the level of ROS in the A549 non-small cell lung …
Restoration Of Phage Growth On A Non-Permissive Host By Bypassing Transcription Termination Signals, Millicent Ronkainen
Restoration Of Phage Growth On A Non-Permissive Host By Bypassing Transcription Termination Signals, Millicent Ronkainen
Mahurin Honors College Capstone Experience/Thesis Projects
RNA polymerase is the central enzyme in all gene expression. The rpoCY75N mutation in the zinc-binding domain of the β’ subunit of E. coli RNA polymerase blocks a unique RNA-based mechanism of transcription antitermination utilized by bacteriophage HK022 and its relatives. Here, we describe the characterization of mutant phage, orc0368, which overcomes the rpoCY75N mutation. The orc0368 genome varies from the wild type phage genome by 4 single base pair mutations. Three of these mutations were not characterized because they occur in intergenic regions but the fourth was chosen for study because of its location between a series …