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Articles 1 - 30 of 34
Full-Text Articles in Life Sciences
Sex Differences In Context Fear Neural Circuitry And Behavior Across Development, Lorianna Marie Colon
Sex Differences In Context Fear Neural Circuitry And Behavior Across Development, Lorianna Marie Colon
Legacy Theses & Dissertations (2009 - 2024)
Over the span of five decades, staggering progress has been made in elucidating the neural circuits involved in fear learning. Research focused on rodents and healthy individuals has been instrumental in elucidating how abnormalities in this circuitry may lend to increased prevalence of various fear and anxiety disorders. However, many of the key findings concerning the acquisition, storage, and retrieval of fear memories have been established in the adult male rodent, leaving a gap in knowledge as to whether females and developing animals process fear and stress inducing information in a similar fashion. Compared to men, women are twice as …
Modulation Of Rho Termination : Expectation Vs Reality, Kavya Sri Sai Chegireddy
Modulation Of Rho Termination : Expectation Vs Reality, Kavya Sri Sai Chegireddy
Legacy Theses & Dissertations (2009 - 2024)
Transcription termination factor Rho is an essential protein in many bacteria. Rho is an ATP-dependent RNA helicase that accounts for 20-50% of termination events in Escherichia coli and plays an important role in preventing pervasive transcription that otherwise might be lethal to bacteria. Rho termination usually occurs in the 3’ UTRs and non-coding regions of the DNA, and the actively transcribing RNA is believed to be protected by translating ribosomes from Rho termination since both transcription and translation are a simultaneous process in prokaryotes. However, in reality, Rho terminates transcription of some protein-coding genes, and fails to terminate transcription of …
Preliminary Results Of Measurements Of Potentially Cancerogenic 1,4-Dioxane In Surface Water Of Twin Lakes Preserve, Wantagh, Ny, Lijo Jose Varghese
Preliminary Results Of Measurements Of Potentially Cancerogenic 1,4-Dioxane In Surface Water Of Twin Lakes Preserve, Wantagh, Ny, Lijo Jose Varghese
Legacy Theses & Dissertations (2009 - 2024)
1,4-dioxane is a volatile organic compound categorized by the United States Environmental Protection agency (EPA, 2017) as a possible human carcinogen potent to cause tumors in humans. Even though this compound poses significant environmental danger when it contaminates water sources, it is surprisingly less studied, and how it behaves in surface water is less understood. The biggest 1,4-dioxane plume in the United States is located in Long Island region of New York. The purpose of this study was to investigate the presence of 1,4-dioxane in surface water and document the influence of existing 1,4-dioxane plume to Twin Lakes Preserve. To …
Elucidating The Relationship Between Recombination Frequency And Antibiotic Resistance In Staphylococcus Aureus, Joseph R. Matthews
Elucidating The Relationship Between Recombination Frequency And Antibiotic Resistance In Staphylococcus Aureus, Joseph R. Matthews
Legacy Theses & Dissertations (2009 - 2024)
Staphylococcus aureus is a common commensal and opportunistic pathogen of humans. It causes a variety of diseases, ranging from skin and soft infections to life-threatening invasive diseases. Many strains of S. aureus have developed resistance to a variety of antibiotic classes, including many beta-lactams. The evolution and dissemination of antibiotic resistance in S. aureus lay in large part to its remarkable ability of acquiring DNA from other organisms through horizontal gene transfer and recombination. In this study, I elucidated the relationship between frequencies of recombination events and horizontally acquired antibiotic resistant genes in a population of S. aureus sampled from …
Molecular Simulation Of Rna Conformational Dynamics : An Example Of Micro-Rna Targeting Messenger Rna : Mir-34a-Msirt1, Parisa Ebrahimi
Molecular Simulation Of Rna Conformational Dynamics : An Example Of Micro-Rna Targeting Messenger Rna : Mir-34a-Msirt1, Parisa Ebrahimi
Legacy Theses & Dissertations (2009 - 2024)
MicroRNA (miRNA), as a distinct class of biological regulators and a ”guide” member of non-coding RNA-protein complexes (RNPs), regulates more than 60% of protein-coding genes expression through base-pairing with targeted messenger RNA (mRNA) in the RNA-Induced Silencing Complex (RISC). Most of miRNAs identified in human, are conserved in other animals, which have preferentially conserved interaction sites particularly in 3’ untranslated regions (3’UTRs) of many human messenger mRNAs.The capability of a single miRNA to target more than hundreds of mRNAs, suggests that miRNAs influence essentially all developmental process and diseases, which also makes them interesting candidates as therapeutics agents. The primary …
Molecular Simulation Of Rna Conformational Dynamics : An Example Of Micro-Rna Targeting Messenger Rna : Mir-34a-Msirt1, Parisa Ebrahimi
Molecular Simulation Of Rna Conformational Dynamics : An Example Of Micro-Rna Targeting Messenger Rna : Mir-34a-Msirt1, Parisa Ebrahimi
Legacy Theses & Dissertations (2009 - 2024)
MicroRNA (miRNA), as a distinct class of biological regulators and a ”guide” member of non-coding RNA-protein complexes (RNPs), regulates more than 60% of protein-coding genes expression through base-pairing with targeted messenger RNA (mRNA) in the RNA-Induced Silencing Complex (RISC). Most of miRNAs identified in human, are conserved in other animals, which have preferentially conserved interaction sites particularly in 3’ untranslated regions (3’UTRs) of many human messenger mRNAs.The capability of a single miRNA to target more than hundreds of mRNAs, suggests that miRNAs influence essentially all developmental process and diseases, which also makes them interesting candidates as therapeutics agents. The primary …
The Evolution Of Sex Differences In Mandrills (Mandrillus Sphinx): Micro- And Macroevolution, Jerred Klint Schafer
The Evolution Of Sex Differences In Mandrills (Mandrillus Sphinx): Micro- And Macroevolution, Jerred Klint Schafer
Legacy Theses & Dissertations (2009 - 2024)
Primates show diverse patterns of adaptive color and body size dimorphism produced by inter- and intrasexual selection. However, the specific microevolutionary processes that produce variation in secondary sexual characteristics remain largely unexplored in primates. Furthermore, sexual conflict theory predicts that female and male secondary sexual traits can coevolve in an antagonistic manner and promote speciation. This dissertation explores the microevolution of secondary sexual characteristics in mandrills (Mandrillus sphinx) and the macroevolution of these characters in anthropoid primates. I address the microevolution of mandrill facial coloration and body mass by estimating the heritability, phenotypic selection, and genetic evolution of these traits …
Isolating Oral Bacterial Species From A Single Donor Through A Multi-Step Detection Method, Khalid Al-Lakhen
Isolating Oral Bacterial Species From A Single Donor Through A Multi-Step Detection Method, Khalid Al-Lakhen
Legacy Theses & Dissertations (2009 - 2024)
The human oral microbiome is one of the most complex microbiome communities in the human body and its role in maintaining health is not fully understood. Previous research shows that the transition from health to disease is accompanied by changes in community abundance and structure. To fully understand the symbiotic relationship formed between bacterial species that leads to the formation of a functional healthy biofilm structure, we must study the various structural relationships and subsequent molecular interactions among individual species within the biofilm. In this thesis, I have isolated a pure bacteria species from a single donor's dental plaque and …
Using Machine Learning To Predict Super-Utilizers Of Healthcare Services, Kevin Paul Buchan Jr.
Using Machine Learning To Predict Super-Utilizers Of Healthcare Services, Kevin Paul Buchan Jr.
Legacy Theses & Dissertations (2009 - 2024)
In this dissertation, I aim to forecast high utilizers of emergency care and inpatient Medicare services (i.e., healthcare visits). Through a literature review, I demonstrate that accurate and reliable prediction of these future high utilizers will not only reduce healthcare costs but will also improve the overall quality of healthcare for patients. By identifying this population at risk before manifestation, I propose that there is still time to reverse undesirable healthcare trajectories (i.e., individuals whose clinical risk increases an excessive healthcare and treatment burden) through timely attention and proper care coordination. My dissertation culminates in the delivery of state-of-the-art predictive …
Expert Level Microscopy For Everyone : Optimizing Microscopy Parameters With Modeling And Simulation, Ethan Woo
Expert Level Microscopy For Everyone : Optimizing Microscopy Parameters With Modeling And Simulation, Ethan Woo
Legacy Theses & Dissertations (2009 - 2024)
Multiplexed fluorescent imaging (MFI) has transformed biological investigation by providing spatial context to labeled analytes, such as DNA, RNA, and proteins. Multiplexed imaging techniques can track multiple analytes at once and thus has the potential to provide an unprecedented view into the complex relationships between various molecules, cells, and tissues. However, most researchers rarely use more than 3 fluorophores at a time due to the complex technological and procedural requirements for highly multiplexed imaging. Currently, a major obstacle in the field is the inability to quantify uncertainty in fluorescent images, making it difficult to draw quantitative conclusions from the images. …
Intergenerational Embodiment Of Stress : How The Broader Sociocultural Environment Can Shape Child Growth And Development, Elizabeth A. Holdsworth
Intergenerational Embodiment Of Stress : How The Broader Sociocultural Environment Can Shape Child Growth And Development, Elizabeth A. Holdsworth
Legacy Theses & Dissertations (2009 - 2024)
Childhood growth has been a means of identifying systemic, material inequalities within populations. The plasticity of growth is responsive to multiple environmental factors, most notably adequate nutrition, but also psychosocial stress. Psychosocial stress can be a function of the social and political economic ecology, reinforcing power hierarchies within societies. This dissertation proposes that childhood growth can also reflect inequality in the distribution of psychosocial stress exposure through mothers’ feelings of a chronically stressful environment conveyed through maternal-infant interactions.
Ampa And Kainate Receptor-Potentiating Rna Aptamers, Janet L. Lynch
Ampa And Kainate Receptor-Potentiating Rna Aptamers, Janet L. Lynch
Legacy Theses & Dissertations (2009 - 2024)
Glutamate receptors act to bring about excitatory transmission in the central nervous system. The receptors are divided into two groups: ionotropic and metabotropic glutamate receptors. Ionotropic glutamate receptors are ion channels which are activated by an agonist such as glutamate or kainate. The main receptors in the ionotropic glutamate receptor family are the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA) receptors. In the central nervous system ionotropic glutamate receptors are found both pre- and postsynaptically. It has been found that most AMPA and NMDA receptors are postsynaptic receptors while the kainate receptors can be pre- or postsynaptic. Underactivity of these …
Assessing The Durability Of The Immune Response Induced By Rivax®, A Ricin Subunit Vaccine, Hayley Lynn Novak
Assessing The Durability Of The Immune Response Induced By Rivax®, A Ricin Subunit Vaccine, Hayley Lynn Novak
Legacy Theses & Dissertations (2009 - 2024)
Assessing the performance and durability of the antibody response in animal models can assist in the development of biodefense vaccines. Ricin is one of the most toxic biological agents known and has been a public health issue for years. Since ricin is easily manufactured and a deadly toxin, rational vaccine design and immunotherapeutic optimization have been explored. RiVax® is a candidate subunit vaccine with a modified A-chain of ricin toxin that was formulated to remove ricin's biological activity. It is thought that RiVax® could serve as a prophylactic that would induce humoral- and cell-mediated immunological responses that elicit protective antigens …
Rna Modification Landscape And Its Contribution To Egg Production, Ian Thomas Rapisarda
Rna Modification Landscape And Its Contribution To Egg Production, Ian Thomas Rapisarda
Legacy Theses & Dissertations (2009 - 2024)
Germline stem cells differentiate into mature egg or sperm cells that go through the process of fertilization which gives rise to all sexually reproducing organisms. During this process of differentiation, germ cells undergo a switch from mitosis to meiosis that allows for proper development and specification of the future gamete. The mechanisms that facilitate this shift from mitosis to meiosis, however, are not well understood. To gain insight into this process, we used Drosophila oogenesis as our model. To identify what RNA modifications are present during oogenesis we genetically enriched for each stage of development and performed mass spectrometry. We …
Characterization Of A Putative Helicase In Rifampicin Resistance Of Mycobacterium Abscessus:, Aavrati Saxena
Characterization Of A Putative Helicase In Rifampicin Resistance Of Mycobacterium Abscessus:, Aavrati Saxena
Legacy Theses & Dissertations (2009 - 2024)
Mycobacterium abscessus (Mab), a non-tuberculous environmental mycobacterium is one of the emerging pathogens. The number of Mab infections has doubled in the past decade. It is also an opportunistic pathogen usually infecting immunocompromised individuals and causing numerous skin and soft tissue infections. It commonly causes lung infections in people who are already infected with one or other lung infections such as tuberculosis. The treatment of Mab infections is difficult because of its intrinsic resistance to most of the antibiotics available. This project studies Rifampicin (RIF) resistance in Mab, as RIF is a well-established treatment for other mycobacterial infections including tuberculosis, …
Missense Mutations In The Gamma Crystallins And Mechanisms Of Lens Opacity, Wenjuan Hou
Missense Mutations In The Gamma Crystallins And Mechanisms Of Lens Opacity, Wenjuan Hou
Legacy Theses & Dissertations (2009 - 2024)
Cataract, or clouding of the ocular lens, among the most common types of eye diseases, is the leading cause of blindness worldwide. With the opacity or clouding of the lens, light incident on the lens is scattered rather than being transmitted and is thus prevented from focusing on the retina. The lens becomes cataractous due to a large number of reasons, among which aging and genetic mutations are two of the most common factors. Clouding of the center of the lens or nuclear opacity, is the most frequently observed type of age-onset cataract, as well as inherited, congenital cataract [1, …
Long Noncoding Rna Ak001796 As A Mediator Of Epithelial-To-Mesenchymal Transition In Metastatic Breast Cancer, Sumayya Adib Alchalabi
Long Noncoding Rna Ak001796 As A Mediator Of Epithelial-To-Mesenchymal Transition In Metastatic Breast Cancer, Sumayya Adib Alchalabi
Legacy Theses & Dissertations (2009 - 2024)
Long noncoding RNAs (lncRNAs) are emerging as key molecules regulating several cellular pathways and contributing to the development and progression of different diseases including cancer. The epithelial-to- mesenchymal transition (EMT), a molecular reprogramming process that plays a critical role in cancer metastasis, involves a complex interaction between protein coding and non-coding transcripts including lncRNAs. Understanding the biological significance of those lncRNAs of relatively unknown function, may help to uncover potential therapeutic targets for the aggressive subtypes of breast and other cancers. In this study, we examined the expression profiles of more than 17,000 lncRNAs in a large set of patients’ …
Role Of Rna Helicases In The Drosophila Germline, Patrick Blatt
Role Of Rna Helicases In The Drosophila Germline, Patrick Blatt
Legacy Theses & Dissertations (2009 - 2024)
Gametogenesis, the process of creating egg or sperm, is required for launching successive generations of sexually reproducing organisms. The developmental milestones that occur during gamete production have been studied for decades and are of critical interest to gain insight to conserved features of human fertility. Drosophila has been used for over a century as an efficient research model and remains pivotal in uncovering fundamental biological paradigms. During Drosophila egg production, or oogenesis, several developmental transitions must be traversed to ensure completion of oogenesis including: Germline Stem Cell (GSC) maintenance and differentiation, mitotic and meiotic cell divisions, and production of maternally …
Mapping Of Auditory Cortical Functions Using Electrocorticography, James Robert Swift
Mapping Of Auditory Cortical Functions Using Electrocorticography, James Robert Swift
Legacy Theses & Dissertations (2009 - 2024)
Communication is a dynamic process through which we translate our inner thoughts in such a way that they can be shared with another person. This complex neurological phenomenon is a key predictor of our productivity and health. When our ability to communicate is compromised, our quality of life suffers. Although numerous methods to investigate the neuroscientific underpinnings of human language exist, our understanding of this process remains incomplete. Improving our understanding of where, when, and how auditory cortical activity occurs can enhance diagnostic techniques and improve treatment methods for neurological conditions that can impact auditory processing, such as epilepsy, or …
Host Factors Affecting Group Ii Intron Retrotransposition, Justin Michael Waldern
Host Factors Affecting Group Ii Intron Retrotransposition, Justin Michael Waldern
Legacy Theses & Dissertations (2009 - 2024)
Group II introns are self-splicing mobile elements that are thought to be the evolutionary ancestors of eukaryotic retrotransposons, the spliceosome, and spliceosomal introns. Yet, little is known about how group II introns have coevolved within their native hosts or about the corresponding host biology.Using the Ll.LtrB intron in its native host, Lactococcus lactis, I first sought to identify host factors that influence retrotransposition. Since retrotransposition can be costly to the host organism, group II introns must achieve a delicate balance between self-proliferation and host preservation. By utilizing the native host organism, my goal was to unearth retrotransposition-related mechanisms that have …
Intrabodies Reveal Critical Steps Involved In Ricin's Interactions With The Ribosome, Timothy Francis Czajka
Intrabodies Reveal Critical Steps Involved In Ricin's Interactions With The Ribosome, Timothy Francis Czajka
Legacy Theses & Dissertations (2009 - 2024)
Ricin is a highly lethal protein toxin derived from the seeds of the castor plant, Ricinus communis. It is a Type II ribosome inactivating protein (RIP), meaning it is a heterodimer with one subunit, ricin toxin B (RTB), that mediates cell surface attachment and intracellular trafficking and a second subunit, ricin toxin A (RTA), that irreversibly shuts down protein synthesis in the cytosol. During trafficking, RTA and RTB necessarily separate in the endoplasmic reticulum, wherein RTA unfolds and translocates into the cytosol where it refolds into an enzymatically active conformation. RTA is remarkably fast acting and efficient, with few molecules …
Kinetic Characterization Of Two C-Family Polymerases From The Gram-Positive Bacterium Staphylococcus Aureus, Sean P. Fagan
Kinetic Characterization Of Two C-Family Polymerases From The Gram-Positive Bacterium Staphylococcus Aureus, Sean P. Fagan
Legacy Theses & Dissertations (2009 - 2024)
In this dissertation, I review the fundamental processes and mechanisms for bacterial DNA replication, especially the mechanisms employed by high-fidelity DNA polymerases to replicate the genome. Unlike the prototypical bacterial system from Escherichia coli which uses a single C-family polymerase, DNA polymerase IIIα (Pol IIIα), to replicate the genome, low-GC content Gram-positive bacteria utilize two essential C-family polymerases, PolC and DnaE. PolC and DnaE work cooperatively to replicate the genome, with DnaE initiating synthesis from RNA-primers and PolC performing the bulk synthesis. Although atomic structures of both PolC and Pol IIIα are available, detailed pre-steady state kinetic analysis of the …
Epitranscriptomic Writer Regulation Of Gene Expression In Escherichia Coli, William Eugene Gasperi
Epitranscriptomic Writer Regulation Of Gene Expression In Escherichia Coli, William Eugene Gasperi
Legacy Theses & Dissertations (2009 - 2024)
The epitranscriptome is composed of enzyme catalyzed RNA modifications that can regulate tRNA, mRNA, and rRNA structure and function. RNA modifications can play key roles in regulating gene expression by controlling the when and how much of translation of specific transcripts. The SelU catalyzed tRNA wobble uridine (U) modification, occurs on tRNA lysine, glutamic acid, and glutamine. We have shown that E. coli deficient in selU gene are more sensitive to the antibiotic chloramphenicol (CAM) than their wild type counterparts. CAM works by inhibiting protein synthesis by binding to the ribosome and preventing peptide chain formation. We hypothesize that SelU …
Development Of Chemical Methods For Oligonucleotide Purification, Paramagnetic Labeling And Synthesis Of Dna-Based Advanced Materials, Muhan He
Legacy Theses & Dissertations (2009 - 2024)
This thesis describes a chemical method for alternative oligonucleotide purification that is non-chromatographic and gel-free and allows to routinely synthesize and purify long functional RNA strands. The purification of long RNAs is based on the bio-orthogonal inverse electron demand Diels-Alder (IEDDA) chemistry between trans-cyclooctene (TCO) and tetrazine (Tz). Target oligonucleotide strands are selectively tagged with Tz and can be captured and purified from the failure sequences with immobilized TCO. RNA strands are synthesized on solid support through a photolabile linker to avoid the loss of Tz tag. Purity of the isolated oligonucleotides was evaluated using gel electrophoresis, HPLC and mass …
The Effects Of 17alpha-Hydroxyprogesterone Caproate On The Development Of The Mesocortical Dopamine Pathway And Cognitive Behavior, Melanie Lolier
The Effects Of 17alpha-Hydroxyprogesterone Caproate On The Development Of The Mesocortical Dopamine Pathway And Cognitive Behavior, Melanie Lolier
Legacy Theses & Dissertations (2009 - 2024)
This dissertation examined the complex developmental impact of the clinically relevant synthetic progestin 17α-hydroxyprogesterone caproate (17-OHPC) on medial prefrontal cortex (mPFC) development. In rodents, the effects of 17-OHPC are subtle, but significant. In the Chapter II, we observed that 17-OHPC abolishes sex differences in dopaminergic fiber innervation and alters microglia phenotype in the prelimbic and infralimbic areas by the end of the first postnatal week. In the third chapter, the overall effect of 17-OHPC on the ontogeny of dopaminergic fiber innervation and synaptic bouton density were used to characterize the timing and duration of treatment effects in the mPFC. In …
The Phosphodiesterase, Rv0805, Is An Unheralded Component Of Tb Complex Mycobacterial Physiology In And Beyond Camp Homeostasis, James R. Mcdowell
The Phosphodiesterase, Rv0805, Is An Unheralded Component Of Tb Complex Mycobacterial Physiology In And Beyond Camp Homeostasis, James R. Mcdowell
Legacy Theses & Dissertations (2009 - 2024)
Phosphodiesterases (PDEs) are integral components of 3’,5’-cyclic adenosine monophosphate (cAMP) signaling pathways by degrading cAMP to modulate the concentration, duration, and localization of the cAMP signal which maintains the specificity of cAMP pathways. The human pathogen, Mycobacterium tuberculosis (Mtb) has a unique cAMP network architecture with at least 15 adenylyl cyclases (ACs) that generate cAMP, but only one characterized PDE, Rv0805, which is found exclusively in pathogenic mycobacteria. Rv0805 can influence Mtb cAMP levels but the absence of Rv0805 orthologs in non-pathogenic mycobacteria and apparent separation of Rv0805 from cAMP directed roles led to numerous questions surrounding PDE function in …
Behavioral, Endocrine, And Neural Responses To Stress In Postpartum And Nulliparous Rats : Potential Mechanisms Of Postpartum Stress Resilience, Joanna Medina
Legacy Theses & Dissertations (2009 - 2024)
Major depressive disorder is one of the most pervasive psychiatric illnesses in the United States. Women are at greater risk for developing depression, particularly during their childbearing years. Approximately 17% of new mothers develop postpartum depression within 4 weeks after parturition. The risk for postpartum depression is even greater in women who do not breastfeed or stop breastfeeding early. Major depressive disorder and postpartum depression share the same symptomology and common etiological bases. Dysregulated stress responses, dopamine activity, and neuroinflammation are recognized mechanisms for depression. The transition to motherhood encompasses physiological and behavioral adaptations in the brain essential for ensuring …
In Search Of Hidden Talents : Stress-Adapted Students, Classroom Characteristics, And Academic Achievement, Jessica Lynn Murray
In Search Of Hidden Talents : Stress-Adapted Students, Classroom Characteristics, And Academic Achievement, Jessica Lynn Murray
Legacy Theses & Dissertations (2009 - 2024)
Differentiated Instruction, an approach to teaching that encourages educators to adjust their content, pedagogy, and assessment based on the needs of individual students, lacks suggestions for how to target specific student groups, such as “high-risk” students. Researchers in the field of evolutionary developmental psychology have begun to focus on stress-adapted students (who are described in a similar way as “high risk” students) and has made suggestions about how to play to the strengths of the cognitive enhancements, or “hidden talents” of these students. When considered together, the work from both fields may provide a clear set of pedagogical recommendations for …
Retrotransposon-Mediated Transduction Of An Environmental Cue To Regulate Centrosome Fate, Shawn Patrick Murphy
Retrotransposon-Mediated Transduction Of An Environmental Cue To Regulate Centrosome Fate, Shawn Patrick Murphy
Legacy Theses & Dissertations (2009 - 2024)
In 1969, the enrichment of mobile element repeat sequences led Britton and Davidson to propose the hypothesis that gene expression in higher eukaryotes is regulated through the exaptation of mobile elements. In this work, I have explored the hypothesis that mobile elements can also be harnessed by the host to regulate asymmetric cell division, thereby determining cell fate. Retrotransposons are ubiquitous eukaryotic mobile elements that transpose through an RNA intermediate. They are often active in cell types that divide asymmetrically to yield daughter cells with different fates, such as embryonic stem cells, germline stem cells, neuronal stem cells and the …
Pre-Steady-State Kinetic Characterization Of An Antibiotic-Resistant Mutation Of Staphylococcus Aureus Polc, Rachel Alice Nelson
Pre-Steady-State Kinetic Characterization Of An Antibiotic-Resistant Mutation Of Staphylococcus Aureus Polc, Rachel Alice Nelson
Legacy Theses & Dissertations (2009 - 2024)
In this dissertation I provide a pre-steady-state kinetic characterization of an antibiotic-resistant mutant of a Staphylococcus aureus DNA polymerase. Staphylococcus aureus is one of the most common causes of infections in humans, and is widely known for its ability to acquire resistance to most antibiotics. Staphylococci infections pose a significant burden to the healthcare system and increase mortality, as more than 95% of Methicillin-Resistant S. aureus (MRSA) infections do not respond to first-line antibiotics. The limited treatment options for Staphylococci infections underscores the need for novel, alternative strategies. In this thesis, I discuss 6-anilinouracils (6-AU), a family of potent dGTP …