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Using A Tnp Fluorophore To Identify Adenosine Binding In The Snap25b Snare Binding Protein, David Hallan, Dixon Woodbury
Using A Tnp Fluorophore To Identify Adenosine Binding In The Snap25b Snare Binding Protein, David Hallan, Dixon Woodbury
Journal of Undergraduate Research
Vesicle fusion is a key step in the cellular process of exocytosis and is at the center of neurotransmitter release by neurons. Fusion is driven by a set of proteins known as SNAREs which includes the protein SNAP25B.
In the synthesis and spectroscopic analysis of the SNAP25B protein, a strong, unexpected 260 nm peak has been seen. This 260 nm peak might correspond to DNA, RNA, or any other adenosine-containing molecule binding to SNAP25B. Previous work indicated that the 260 peak was not due to DNA or RNA. SNAP25B binding to an adenosine-containing substance could be the basis of an …